Browsing by Author "Solis, Eric"
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Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
Solis, Eric John (2016-05-14)Despite its eponymous association with proteotoxic stress, heat shock factor 1 (Hsf1 in yeast and HSF1 in mammals) is required for viability of yeast and many human cancer cells, yet its essential role remains undefined. ... -
Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
Solis, Eric John; Pandey, Jai P.; Zheng, Xu; Jin, Dexter X.; Gupta, Piyush B.; Airoldi, Edoardo Maria; Pincus, David Frank; Denic, Vladimir (Elsevier BV, 2016)Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is essential even at low temperatures. Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associated ...