Browsing by Author "Travison, Thomas"
Now showing items 1-11 of 11
-
Alzheimer's-Related Cortical Atrophy Is Associated With Postoperative Delirium Severity in Persons Without Dementia
Racine, Annie M.; Fong, Tamara; Travison, Thomas; Jones, Richard N.; Gou, Yun; Vasunilashorn, Sarinnapha; Marcantonio, Edward; Alsop, David; Inouye, Sharon; Dickerson, Bradford (Elsevier BV, 2017-11)Patients with dementia due to Alzheimer’s disease (AD) have increased risk of developing delirium. This study investigated the relationship between a magnetic resonance imaging (MRI)-derived biomarker associated with ... -
Association Between Hospital Readmission and Acute and Sustained Delays in Functional Recovery During 18 Months After Elective Surgery: The Successful Aging after Elective Surgery Study
Pisani, Margaret A.; Albuquerque, Asha; Marcantonio, Edward; Jones, Richard N.; Gou, Ray Yun; Fong, Tamara; Schmitt, Eva M.; Tommet, Douglas; Isaza Aizpurua, Ilean I.; Alsop, David; Inouye, Sharon; Travison, Thomas (Wiley, 2017-01)Objectives: To examine the effect of hospital readmission on functional recovery after elective surgery in older adults. Design: Prospective cohort of individuals aged 70 and older undergoing elective surgery, enrolled ... -
Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy
Jasuja, Ravi; Costello, James C; Singh, Rajan; Gupta, Vandana; Spina, Catherine S; Toraldo, Gianluca; Jang, Hyeran; Li, Hu; Serra, Carlo; Guo, Wen; Chauhan, Pratibha; Narula, Navjot S; Guarneri, Tyler; Ergun, Ayla; Travison, Thomas G; Collins, James J; Bhasin, Shalender (BlackWell Publishing Ltd, 2013)Because of its anabolic effects on muscle, testosterone is being explored as a function-promoting anabolic therapy for functional limitations associated with aging; however, concerns about testosterone’s adverse effects ... -
Delirium Severity Post-Surgery and its Relationship with Long-Term Cognitive Decline in a Cohort of Patients without Dementia
Vasunilashorn, Sarinnapha; Fong, Tamara G; Albuquerque, Asha; Marcantonio, Edward Ralph; Schmitt, Eva M.; Tommet, Douglas; Gou, Yun; Travison, Thomas G; Jones, Richard N.; Inouye, Sharon K. (IOS Press, 2017)Background: Delirium has been associated with more rapid cognitive decline. However, it is unknown whether increased delirium severity is associated with a higher rate of long-term cognitive decline. Objective: To evaluate ... -
Elevated circulating vascular cell Adhesion Molecule-1 (sVCAM-1) is associated with concurrent depressive symptoms and cerebral white matter Hyperintensities in older adults
Tchalla, Achille E.; Wellenius, Gregory A.; Sorond, Farzaneh A.; Travison, Thomas G.; Dantoine, Thierry; Lipsitz, Lewis A. (BioMed Central, 2015)Background: Circulating vascular adhesion molecule-1 (sVCAM-1) is a presumed marker of endothelial activation and dysfunction, but little is known about its association with mood. We hypothesized that elevated plasma ... -
Heritability of Thoracic Spine Curvature and Genetic Correlations With Other Spine Traits: The Framingham Study
Yau, Michelle Szu-Huei; Demissie, Serkalem; Zhou, Yanhua; Anderson, Dennis Earl; Lorbergs, Amanda L; Kiel, Douglas P; Allaire, Brett T; Yang, Laiji; Cupples, L Adrienne; Travison, Thomas G; Bouxsein, Mary Larsen; Karasik, David; Samelson, Elizabeth J. (Wiley, 2016)Hyperkyphosis is a common spinal disorder in older adults, characterized by excessive forward curvature of the thoracic spine and adverse health outcomes. The etiology of hyperkyphosis has not been firmly established, but ... -
The Method of Randomization for Cluster-Randomized Trials: Challenges of Including Patients with Multiple Chronic Conditions
Esserman, Denise; Allore, Heather G.; Travison, Thomas G. (2016)Cluster-randomized clinical trials (CRT) are trials in which the unit of randomization is not a participant but a group (e.g. healthcare systems or community centers). They are suitable when the intervention applies naturally ... -
Patterns, Predictors, and Outcomes of Falls Trajectories in Older Adults: The MOBILIZE Boston Study with 5 Years of Follow-Up
Tchalla, Achille E.; Dufour, Alyssa B.; Travison, Thomas G.; Habtemariam, Daniel; Iloputaife, Ikechukwu; Manor, Brad; Lipsitz, Lewis A. (Public Library of Science, 2014)Background: Falls may occur as unpredictable events or in patterns indicative of potentially modifiable risks and predictive of adverse outcomes. Knowing the patterns, risks, and outcomes of falls trajectories may help ... -
Preoperative Cognitive Performance Dominates Risk for Delirium Among Older Adults
Jones, Richard N.; Marcantonio, Edward; Saczynski, Jane S.; Tommet, Douglas; Gross, Alden L.; Travison, Thomas; Alsop, David; Schmitt, Eva M.; Fong, Tamara; Cizginer, Sevdenur; Shafi, Mouhsin; Pascual-Leone, Alvaro; Inouye, Sharon (SAGE Publications, 2016-11)Background Cognitive impairment is a well-recognized risk factor for delirium. Our goal was to determine if the level of cognitive performance across the non-demented cognitive ability spectrum is correlated with delirium ... -
The Short-Term and Long-Term Relationship Between Delirium and Cognitive Trajectory in Older Surgical Patients
Inouye, Sharon; Marcantonio, Edward; Kosar, Cyrus M.; Tommet, Douglas; Schmitt, Eva M.; Travison, Thomas; Saczynski, Jane S.; Ngo, Long; Alsop, David; Jones, Richard N. (Wiley, 2016-07)INTRODUCTION Since the relationship between delirium and long-term cognitive decline has not been well-explored, we evaluated this association in a prospective study. METHODS SAGES is an on-going study involving 560 ... -
The Successful Aging After Elective Surgery Study: Cohort Description and Data Quality Procedures
Schmitt, Eva M.; Saczynski, Jane S.; Kosar, Cyrus M.; Jones, Richard N.; Alsop, David C.; Fong, Tamara G.; Metzger, Eran; Cooper, Zara R; Marcantonio, Edward Ralph; Travison, Thomas G; Inouye, Sharon K. (Wiley-Blackwell, 2015)Background/Objectives Delirium is the most common complication of major elective surgery in older patients. The Successful Aging after Elective Surgery (SAGES) study was designed to examine novel risk factors and long-term ...