Now showing items 1-2 of 2

    • A New Class of Small Molecule Inhibitor of BMP Signaling 

      Sanvitale, Caroline E.; Kerr, Georgina; Chaikuad, Apirat; Ramel, Marie-Christine; Mohedas, Agustin Humberto; Reichert, Sabine; Wang, You; Triffitt, James T.; Cuny, Gregory D.; Yu, Paul B.; Hill, Caroline S.; Bullock, Alex N. (Public Library of Science, 2013)
      Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small molecule inhibitors of the bone morphogenetic protein (BMP) receptor ...
    • Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification 

      Dey, D.; Bagarova, J.; Hatsell, S. J.; Armstrong, K. A.; Huang, L.; Ermann, J.; Vonner, A. J.; Shen, Y.; Mohedas, Agustin Humberto; Lee, A.; Eekhoff, E. M. W.; van Schie, A.; Demay, Marie Bernadette; Keller, C.; Wagers, Amy Jo; Economides, A. N.; Yu, P. B. (American Association for the Advancement of Science (AAAS), 2016)
      Fibrodysplasia ossificans progressiva (FOP), a congenital HO syndrome caused by gain-of-function mutations of bone morphogenetic protein (BMP) type I receptor ACVR1, manifests with progressive ossification of diverse tissues ...