Now showing items 1-11 of 11

    • Common Genetic Variation and the Control of HIV-1 in Humans 

      Fellay, Jacques; Ge, Dongliang; Shianna, Kevin V.; Colombo, Sara; Ledergerber, Bruno; Cirulli, Elizabeth T.; Urban, Thomas J.; Zhang, Kunlin; Gumbs, Curtis E.; Castagna, Antonella; Cozzi-Lepri, Alessandro; De Luca, Andrea; Easterbrook, Philippa; Günthard, Huldrych F.; Mallal, Simon; Mussini, Cristina; Dalmau, Judith; Martinez-Picado, Javier; Miro, José M.; Obel, Niels; Wolinsky, Steven M.; Martinson, Jeremy J.; Detels, Roger; Margolick, Joseph B.; Jacobson, Lisa P.; Descombes, Patrick; Antonarakis, Stylianos E.; Beckmann, Jacques S.; McMichael, Andrew J.; Haynes, Barton F.; Carrington, Mary; Telenti, Amalio; Goldstein, David B.; NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI); Smith, Jason P.; O'Brien, Stephen James; Letvin, Norman Lee; Feng, Sheng (Public Library of Science, 2009)
      To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic ...
    • Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys 

      Chan, Tiffany; O'Brien, Kara L.; Goldstein, David B.; Haynes, Barton F.; Malik, Harmit S.; Lim, So-Yon; Gelman, Rebecca Sue; Whitney, James B.; Barouch, Dan Hung; Letvin, Norman Lee (Public Library of Science, 2010)
      CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 ...
    • A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis 

      Chen, Crystal Y.; Shen, Ling; Zeng, Gucheng; Yao, Shuyun; Shen, Yun; Halliday, Lisa; Fortman, Jeff; McAllister, Milton; Estep, Jim; Vasconcelos, Daphne; Du, George; Porcelli, Steven A.; Larsen, Michelle H.; Jacobs, William R.; Haynes, Barton F.; Letvin, Norman Lee; Huang, Dan; Wang, Richard; Hunt, Robert; Chen, Zheng-Yi (Public Library of Science, 2009)
      The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell–mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman ...
    • Genital Tract Sequestration of SIV following Acute Infection 

      Whitney, James B.; Hraber, Peter T.; Luedemann, Corinne; Giorgi, Elena E.; Daniels, Marcus G.; Bhattacharya, Tanmoy; Rao, Srinivas S.; Mascola, John R.; Nabel, Gary J.; Korber, Bette T.; Letvin, Norman Lee (Public Library of Science, 2011)
      We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. ...
    • Local Replication of Simian Immunodeficiency Virus in the Breast Milk Compartment of Chronically-infected, Lactating Rhesus Monkeys 

      Permar, Sallie Robey; Kang, Helen H; Wilks, Andrew B; Mach, Linh V; Carville, Angela A L; Mansfield, Keith G.; Learn, Gerald H; Hahn, Beatrice H; Letvin, Norman Lee (BioMed Central, 2010)
      Breast milk transmission remains a major mode of infant HIV acquisition, yet anatomic and immunologic forces shaping virus quasispecies in milk are not well characterized. In this study, phylogenic analysis of envelope ...
    • Low-Dose Rectal Inoculation of Rhesus Macaques by SIVsmE660 or SIVmac251 Recapitulates Human Mucosal Infection by HIV-1 

      Keele, Brandon F.; Learn, Gerald H.; Hraber, Peter; Giorgi, Elena E.; Grayson, Truman; Sun, Chuanxi; Chen, Yalu; Mascola, John R.; Nabel, Gary J.; Haynes, Barton F.; Bhattacharya, Tanmoy; Perelson, Alan S.; Korber, Bette T.; Hahn, Beatrice H.; Shaw, George M.; Li, Hui; Yeh, Wendy Wen-Li; Letvin, Norman Lee (Rockefeller University Press, 2009)
      We recently developed a novel strategy to identify transmitted HIV-1 genomes in acutely infected humans using single-genome amplification and a model of random virus evolution. Here, we used this approach to determine the ...
    • P01-01. The Blood Transcriptional Response to Early Acute HIV Infection is Transient and Responsive to Antiretroviral Therapy 

      Skinner, JA; Baldwin, N; Lemoine, B; Blankenship, D; De Vol, EB; Mejias, A; Ramilo, O; Soderberg, K; Denny, TN; Shianna, K; McMichael, A; Banchereau, J; Chaussabel, D; Sharma, M; Cohen, M; Letvin, Norman Lee; Goldstein, D; Haynes, B (BioMed Central, 2009)
      Background: Systemic events in acute HIV infection (AHI) are associated with disease severity and progression to AIDS. Timely identification of AHI patients has posed a significant challenge to identifying the underlying ...
    • P03-07. Autologous Neutralizing Antibodies That Select Viral Escape Variants Emerge Late After SIV Infection of Rhesus Monkeys 

      Rahman, I; Hraber, P; Giri, A; Nevidomskyte, D; Coffey, RT; Miljkovic, S; Keele, BF; Shaw, GM; Korber, BT; Yeh, Wendy Wen-Li; Asmal, Mohammed; Whitney, James B.; Seaman, Michael S.; Letvin, Norman Lee (BioMed Central, 2009)
    • P04-41. Kinetics of Antibody Neutralization and Viral Evolution Following Envelope Vaccination in SIV-infected Rhesus Monkeys 

      Basavapathruni, A; Coffey, R; Hraber, P; Giri, A; Mascola, J; Nabel, G; Korber, B; Yeh, Wendy Wen-Li; Whitney, James B.; Rao, Sowmya R.; Seaman, Michael S.; Letvin, Norman Lee (BioMed Central, 2009)
      Poster presentation. Conclusion: Our results indicate that env vaccination is associated with an accelerated development of autologous neutralizing antibodies. These antibodies were focused at least in part on the V1 region ...
    • P17-09. Immunization with a Single HIV-1 Envelope Sequence Can Generate CD8+ T lymphocytes Capable of Recognizing Multiple Variant Forms of Envelope 

      Hulot, SL; Seaman, Michael S.; Dorosh, LA; Korber, BT; Letvin, Norman Lee (BioMed Central, 2009)
      Background: The ability of CD8+ T lymphocytes to recognize a diversity of mutant forms of an HIV epitope is of central importance in the immune containment of this virus. The present studies were pursued to determine the ...
    • P19-57 LB. Gene-Based Vaccination Protects Against Mucosal Infection by a Heterologous Highly Pathogenic SIV Isolate in Rhesus Monkeys 

      Mascola, J; Buzby, A; Roederer, M; Hudgens, M; Gilbert, P; Seder, R; Douek, D; Koup, R; Nabel, G; Letvin, Norman Lee; Rao, S; Graham, B (BioMed Central, 2009)