Now showing items 1-8 of 8

    • The Aromatase Gene (CYP19A1) Variants and Circulating Hepatocyte Growth Factor in Postmenopausal Women 

      Lin, Jennifer H.; Gunter, Marc J.; Manson, JoAnn Elisabeth; Rexrode, Kathryn Marian; Cook, Nancy Romanowicz; Kraft, Peter; Cochrane, Barbara B.; Chlebowski, Rowan T.; Ho, Gloria Y. F.; Zhang, Shumin (Public Library of Science, 2012)
      Background: Estrogen and androgen have been linked to the regulation of circulating hepatocyte growth factor (HGF), an adipose tissue-derived cytokine. It is possible that the CYP19A1 gene which alters sex hormones production ...
    • Comparison of Self-Reported and Accelerometer-Assessed Physical Activity in Older Women 

      Shiroma, Eric J.; Cook, Nancy R.; Manson, JoAnn E.; Buring, Julie E.; Rimm, Eric B.; Lee, I-Min (Public Library of Science, 2015)
      Background: Self-reported physical activity measures continue to be validated against accelerometers; however, the absence of standardized, accelerometer moderate-to-vigorous physical activity (MVPA) definitions has made ...
    • Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Women 

      Song, Yiqing; Cook, Nancy Romanowicz; Albert, Christine Marie; Van Denburgh, Martin; Manson, JoAnn Elisabeth (American Diabetes Association, 2009)
      OBJECTIVE: Homocysteinemia may play an etiologic role in the pathogenesis of type 2 diabetes by promoting oxidative stress, systemic inflammation, and endothelial dysfunction. We investigated whether homocysteine-lowering ...
    • Environmental Chemicals in Urine and Blood: Improving Methods for Creatinine and Lipid Adjustment 

      O’Brien, Katie M.; Upson, Kristen; Cook, Nancy R.; Weinberg, Clarice R. (National Institute of Environmental Health Sciences, 2015)
      Background: Investigators measuring exposure biomarkers in urine typically adjust for creatinine to account for dilution-dependent sample variation in urine concentrations. Similarly, it is standard to adjust for serum ...
    • Kidney function and risk of cardiovascular disease and mortality in women: a prospective cohort study 

      Kurth, Tobias; de Jong, Paul E; Cook, Nancy Romanowicz; Buring, Julie Elizabeth; Ridker, Paul M. (BMJ Publishing Group Ltd., 2009)
      Objective: To evaluate the association of kidney function with cardiovascular disease and mortality among apparently healthy women. Design: Prospective cohort study. Setting: Women’s Health Study, United States. Participants: ...
    • Lifestyle‐Based Prediction Model for the Prevention of CVD: The Healthy Heart Score 

      Chiuve, Stephanie E.; Cook, Nancy R.; Shay, Christina M.; Rexrode, Kathryn M.; Albert, Christine M.; Manson, JoAnn E.; Willett, Walter C.; Rimm, Eric B. (Blackwell Publishing Ltd, 2014)
      Background: Clinical practice focuses on the primary prevention of cardiovascular (CV) disease (CVD) through the modification and pharmacological treatment of elevated risk factors. Prediction models based on established ...
    • Novel genetic markers improve measures of atrial fibrillation risk prediction 

      Everett, Brendan M.; Cook, Nancy R.; Conen, David; Chasman, Daniel I.; Ridker, Paul M; Albert, Christine M. (Oxford University Press, 2013)
      Aims Atrial fibrillation (AF) is associated with adverse outcome. Whether recently discovered genetic risk markers improve AF risk prediction is unknown. Methods and results We derived and validated a novel AF risk prediction ...
    • A Randomized Trial of Low-Dose Aspirin in the Prevention of Clinical Type 2 Diabetes in Women 

      Pradhan, Aruna Das; Cook, Nancy Romanowicz; Manson, JoAnn Elisabeth; Ridker, Paul M.; Buring, Julie Elizabeth (American Diabetes Association, 2009)
      OBJECTIVE—Subclinical inflammation is linked with the development of type 2 diabetes, and epidemiologic data suggest that this association may be stronger in women. Although small clinical studies have shown a prominent ...