Browsing by Author "Flanagan, John"
Now showing items 1-5 of 5
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Hyperactive alpha2-chimaerin reveals the complexity of axon guidance signaling pathways in motor neuron development
Nugent, Alicia Anne (2016-04-14)α2-chimaerin has striking importance for proper neural circuit formation. Individuals with gain-of-function mutations in α2-chimaerin have Duane retraction syndrome, a common neurogenic eye movement disorder, and α2-chimaerin ... -
Lineage and Functional Analyses of Specific Subsets of Retinal Progenitor Cells
You, Wenjia (2015-05-21)The vertebrate central nervous system (CNS) is made up of a diverse array of cell types. The retina, an accessible part of the CNS with seven major cell types and more than sixty cell subtypes, is an excellent model system ... -
Regulation of Neural Progenitor Cell State by Ephrin-B
Qiu, Runxiang; Wang, Xiuyun; Davy, Alice; Wu, Chen; Murai, Kiyohito; Zhang, Heying; Flanagan, John Gerard; Soriano, Philippe; Lu, Qiang (The Rockefeller University Press, 2008)Maintaining a balance between self-renewal and differentiation in neural progenitor cells during development is important to ensure that correct numbers of neural cells are generated. We report that the ephrin-B–PDZ-RGS3 ... -
The Roles of RNA-binding Proteins in the Developing Nervous System
Quan, Jie (2014-02-25)RNA-binding proteins are key players in post-transcriptional regulation of gene expression by orchestrating RNA fate from synthesis to decay. Hundreds of proteins with RNA-binding capacity have been identified so far, yet ... -
Transcriptional Controls Over Specification of Neocortical Projection Neuron Subtype and Area Identity
Custo Greig, Luciano F. (2015-08-04)The complex and sophisticated neocortical circuits that mediate higher-order brain functions are assembled from an extraordinary variety of neuronal subtypes, each with distinct morphologies, output connectivity, and ...