Now showing items 1-5 of 5

    • CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells 

      Chen, Zhangguo; Chen, Lanfen; Olszak, Torsten; Zeissig, Sebastian; Kuo, Timothy T.; Mandelboim, Ofer; Beauchemin, Nicole; Lanier, Lewis L.; Baker, Kristi Dorothy; Huang, Yu-Hwa; Blumberg, Richard Steven (The Rockefeller University Press, 2011)
      Although carcinoembryonic antigen (CEA)–related cell adhesion molecule 1 (CEACAM1) has been viewed as a tumor suppressor, increasing clinical evidence shows that high levels of CEACAM1 expression on tumors correlates ...
    • Neonatal Fc Receptor: From Immunity to Therapeutics 

      Kuo, Timothy Ting-Chang; Baker, Kristi Dorothy; Yoshida, Masaru; Qiao, Shuo-Wang; Aveson, Victoria G.; Lencer, Wayne Isaac; Blumberg, Richard Steven (Springer US, 2010)
      The neonatal Fc receptor (FcRn), also known as the Brambell receptor and encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial ...
    • Neonatal Fc receptors for IgG drive CD8+ T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites 

      Baker, Kristi; Rath, Timo; Pyzik, Michal; Blumberg, Richard S (Landes Bioscience, 2014)
      Mucosal boundaries, which are immunologically tolerogenic, and is further enhanced by undergo malignant transformation at high rates. We have identified the expression of neonatal Fc receptor for IgG (FcRn) by dendritic ...
    • Regulation of Immune Responses by the Neonatal Fc Receptor and Its Therapeutic Implications 

      Rath, Timo; Baker, Kristi; Pyzik, Michal; Blumberg, Richard S. (Frontiers Media S.A., 2015)
      As a single receptor, the neonatal Fc receptor (FcRn) is critically involved in regulating albumin and IgG serum concentrations by protecting these two ligands from degradation. In addition to these essential homeostatic ...
    • The Role of FcRn in Antigen Presentation 

      Baker, Kristi; Rath, Timo; Pyzik, Michal; Blumberg, Richard S. (Frontiers Media S.A., 2014)
      Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the ...