Now showing items 1-20 of 27

    • Adherence is a multi-dimensional construct in the POUNDS LOST trial 

      Williamson, Donald A.; Anton, Stephen D.; Han, Hongmei; Champagne, Catherine M.; Allen, Ray; LeBlanc, Eric; Ryan, Donna H.; McManus, Katherine; Laranjo, Nancy M; Carey, Vincent James; Loria, Catherine M.; Bray, George A.; Sacks, Frank Martin (Springer Nature, 2009)
      Research on the conceptualization of adherence to treatment has not addressed a key question: Is adherence best defined as being a uni-dimensional or multi-dimensional behavioral construct? The primary aim of this study ...
    • The Bioconductor channel in F1000Research 

      Huber, Wolfgang; Carey, Vincent; Davis, Sean; Hansen, Kasper Daniel; Morgan, Martin (F1000Research, 2015)
      Bioconductor ( bioconductor.org) is a rich source of software and know-how for the integrative analysis of genomic data. The Bioconductor channel in F1000Research provides a forum for task-oriented workflows that each cover ...
    • Combining Effects from Rare and Common Genetic Variants in an Exome-Wide Association Study of Sequence Data 

      Aschard, Hugues; Qiu, Weiliang; Pasaniuc, Bogdan; Zaitlen, Noah; Cho, Michael Hyosang; Carey, Vincent James (BioMed Central, 2011)
      Recent breakthroughs in next-generation sequencing technologies allow cost-effective methods for measuring a growing list of cellular properties, including DNA sequence and structural variation. Next-generation sequencing ...
    • Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates 

      Sacks, Frank Martin; Bray, George A.; Carey, Vincent James; Smith, Steven R.; Ryan, Donna H.; Anton, Stephen D.; McManus, Katherine; Champagne, Catherine M.; Bishop, Louise M.; Laranjo, Nancy M; Leboff, Meryl Susan; Rood, Jennifer Evelyn; de Jonge, Lilian; Greenway, Frank L.; Loria, Catherine M.; Obarzanek, Eva; Williamson, Donald A. (New England Journal of Medicine (NEJM/MMS), 2009)
      BACKGROUND: The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year. METHODS: We randomly assigned ...
    • Contribution of High Plasma Triglycerides and Low High-Density Lipoprotein Cholesterol to Residual Risk of Coronary Heart Disease After Establishment of Low-Density Lipoprotein Cholesterol Control 

      Carey, Vincent James; Bishop, Louise M.; Laranjo, Nancy M; Harshfield, Benjamin J.; Kwiat, Carolyn; Sacks, Frank Martin (Elsevier BV, 2010)
      To determine the relative contributions of triglycerides (TGs) and high-density lipoprotein (HDL) cholesterol in the residual risk of coronary heart disease (CHD) after the reduction of low-density lipoprotein (LDL) ...
    • Diarrhea as a cause of mortality in a mouse model of infectious colitis 

      Borenshtein, Diana; Fry, Rebecca C; Groff, Elizabeth B; Nambiar, Prashant R; Carey, Vincent James; Fox, James G; Schauer, David B (BioMed Central, 2008)
      Background: Comparative characterization of genome-wide transcriptional changes during infection can help elucidate the mechanisms underlying host susceptibility. In this study, transcriptional profiling of the mouse ...
    • Early behavioral adherence predicts short and long-term weight loss in the POUNDS LOST study 

      Williamson, Donald A.; Anton, Stephen D.; Han, Hongmei; Champagne, Catherine M.; Allen, Ray; LeBlanc, Eric; Ryan, Donna H.; Rood, Jennifer Evelyn; McManus, Katherine; Laranjo, Nancy M; Carey, Vincent James; Loria, Catherine M.; Bray, George A.; Sacks, Frank Martin (Springer Nature, 2010)
      The primary aim of this study was to test the association of early (first 6 months) adherence related to diet, self-monitoring, and attendance with changes in adiposity and cardiovascular risk factors. This study used data ...
    • Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial. 

      Furtado, Jeremy Daniel; Campos, Hannia; Appel, Lawrence; Miller, Edgar; Laranjo, Nancy M; Carey, Vincent James; Sacks, Frank Martin (American Society for Nutrition, 2008)
    • Effect of type and amount of dietary carbohydrate on biomarkers of glucose homeostasis and C reactive protein in overweight or obese adults: results from the OmniCarb trial 

      Juraschek, Stephen P; Miller, Edgar R; Selvin, Elizabeth; Carey, Vincent J; Appel, Lawrence J; Christenson, Robert H; Sacks, Frank M (BMJ Publishing Group, 2016)
      Objective: The glycemic index (GI) of dietary carbohydrate is thought to affect glucose homeostasis. Recently, the Effect of Amount and Type of Dietary Carbohydrates on Risk for Cardiovascular Heart Disease and Diabetes ...
    • Effects of High vs Low Glycemic Index of Dietary Carbohydrate on Cardiovascular Disease Risk Factors and Insulin Sensitivity 

      Sacks, Frank Martin; Carey, Vincent James; Anderson, Cheryl A. M.; Miller, Edgar R.; Copeland, Trisha; Charleston, Jeanne; Harshfield, Benjamin J.; Laranjo, Nancy M; McCarron, Phyllis; Swain, Janis; White, Karen; Yee, Karen; Appel, Lawrence J. (American Medical Association (AMA), 2014)
      Importance Foods that have similar carbohydrate content can differ in the amount they raise blood glucose. The effects of this property, called the glycemic index, on risk factors for cardiovascular disease and diabetes ...
    • Effects of Protein, Monounsaturated Fat, and Carbohydrate Intake on Blood Pressure and Serum Lipids 

      Appel, Lawrence J.; Sacks, Frank Martin; Carey, Vincent James; Obarzanek, Eva; Swain, Janis F.; Miller, Edgar R.; Conlin, Paul Richard; Erlinger, Thomas P.; Rosner, Bernard Alfred; Laranjo, Nancy M; Charleston, Jeanne; McCarron, Phyllis; Bishop, Louise M.; OmniHeart Collaborative Research Group, for the (American Medical Association (AMA), 2005)
    • Expression analysis of asthma candidate genes during human and murine lung development 

      Melén, Erik; Kho, Alvin Thong-Juak; Sharma, Sunita; Gaedigk, Roger; Leeder, J Steven; Mariani, Thomas J; Carey, Vincent James; Weiss, Scott Tillman; Tantisira, Kelan (Springer Science + Business Media, 2011)
      Background: Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for later lung ...
    • Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation 

      Croteau-Chonka, Damien C.; Rogers, Angela J.; Raj, Towfique; McGeachie, Michael J.; Qiu, Weiliang; Ziniti, John P.; Stubbs, Benjamin J.; Liang, Liming; Martinez, Fernando D.; Strunk, Robert C.; Lemanske, Robert F.; Liu, Andrew H.; Stranger, Barbara E.; Carey, Vincent J.; Raby, Benjamin A. (Public Library of Science, 2015)
      Disease-associated loci identified through genome-wide association studies (GWAS) frequently localize to non-coding sequence. We and others have demonstrated strong enrichment of such single nucleotide polymorphisms (SNPs) ...
    • Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene 

      Himes, Blanca Elena; Jiang, Xiaofeng; Hu, Ruoxi; Wu, Ann Chen; Su, Jessica Ann Lasky; Klanderman, Barbara J.; Ziniti, John; Senter-Sylvia, Jody; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Meyers, Deborah A.; Bleecker, Eugene R.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Hanrahan, John P.; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Panettieri, Reynold A.; Markezich, Amy; Israel, Elliot; Carey, Vincent James; Tantisira, Kelan; Litonjua, Augusto Ampil; Lu, Quan; Weiss, Scott Tillman (Public Library of Science, 2012)
      Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the ...
    • A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes 

      Sharma, Sunita; Zhou, Xiaobo; Thibault, Derek M.; Himes, Blanca E.; Liu, Andy; Szefler, Stanley J.; Strunk, Robert; Castro, Mario; Hansel, Nadia N.; Diette, Gregory B.; Vonakis, Becky M.; Adkinson, N. Franklin; Avila, Lydiana; Soto-Quiros, Manuel; Barraza-Villareal, Albino; Lemanske, Robert F.; Solway, Julian; Krishnan, Jerry; White, Steven R.; Cheadle, Chris; Berger, Alan E.; Fan, Jinshui; Boorgula, Meher Preethi; Nicolae, Dan; Gilliland, Frank; Barnes, Kathleen; London, Stephanie J.; Martinez, Fernando; Ober, Carole; Celedón, Juan C.; Carey, Vincent James; Weiss, Scott Tillman; Raby, Benjamin Alexander (Elsevier BV, 2014)
      Background: Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes ...
    • A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes 

      Sharma, Sunita; Zhou, Xiaobo; Thibault, Derek M.; Himes, Blanca; Liu, Andy; Szefler, Stanley J.; Strunk, Robert; Castro, Mario; Hansel, Nadia N.; Diette, Gregory B.; Vonakis, Becky M.; Adkinson, N. Franklin; Avila, Lydiana; Soto-Quiros, Manuel; Barraza-Villareal, Albino; Lemanske, Robert F.; Solway, Julian; Krishnan, Jerry; White, Steven James; Cheadle, Chris; Berger, Alan E.; Fan, Jinshui; Boorgula, Meher Preethi; Nicolae, Dan; Gilliland, Frank; Barnes, Kathleen; London, Stephanie J.; Martinez, Fernando; Ober, Carole; Celedón, Juan C.; Carey, Vincent James; Weiss, Scott Tillman; Raby, Benjamin Alexander (Elsevier BV, 2014)
      Background: Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes ...
    • A graphical model approach for inferring large-scale networks integrating gene expression and genetic polymorphism 

      Chu, Jen-Hwa; Weiss, Scott Tillman; Carey, Vincent James; Raby, Benjamin Alexander (BioMed Central, 2009)
      Background: Graphical models (e.g., Bayesian networks) have been used frequently to describe complex interaction patterns and dependent structures among genes and other phenotypes. Estimation of such networks has been a ...
    • A Multisite Randomized Trial of the Effects of Physician Education and Organizational Change in Chronic-Asthma Care 

      Lozano, Paula; Finkelstein, Jonathan Arie; Carey, Vincent James; Wagner, Edward W.; Inui, Thomas S.; Fuhlbrigge, Anne Louise; Soumerai, Stephen Bertram; Sullivan, Sean D.; Weiss, Scott Tillman; Weiss, Kevin (American Medical Association (AMA), 2004)
      Background Traditional primary care practice change approaches have not led to full implementation of national asthma guidelines. Objective To evaluate the effectiveness of 2 asthma care improvement strategies in ...
    • Obesity favors apolipoprotein E- and C-III-containing high density lipoprotein subfractions associated with risk of heart disease 

      Talayero, B.; Wang, Lang; Furtado, Jeremy Daniel; Carey, Vincent James; Bray, G. A.; Sacks, Frank Martin (American Society for Biochemistry & Molecular Biology (ASBMB), 2014)
      Human HDLs have highly heterogeneous composition. Plasma concentrations of HDL with apoC-III and of apoE in HDL predict higher incidence of coronary heart disease (CHD). The concentrations of HDL-apoA-I containing apoE, ...
    • Platform dependence of inference on gene-wise and gene-set involvement in human lung development 

      Bhattacharya, Soumyaroop; Metje, Stephanie; Gaedigk, Roger; Mariani, Thomas J; Leeder, J Steven; Du, Rose; Tantisira, Kelan; Carey, Vincent James; Kho, Alvin Thong-Juak; Klanderman, Barbara Jordan; Lazarus, Ross; Weiss, Scott Tillman (BioMed Central, 2009)
      Background: With the recent development of microarray technologies, the comparability of gene expression data obtained from different platforms poses an important problem. We evaluated two widely used platforms, Affymetrix ...