Now showing items 1-20 of 72

    • Abnormal white matter microstructure and increased extracellular free-water in the cingulum bundle associated with delusions in chronic schizophrenia 

      Oestreich, Lena K.L.; Pasternak, Ofer; Shenton, Martha E.; Kubicki, Marek; Gong, Xue; McCarthy-Jones, Simon; Whitford, Thomas J. (Elsevier, 2016)
      Background: There is growing evidence to suggest that delusions associated with schizophrenia arise from altered structural brain connectivity. The present study investigated whether structural changes in three major ...
    • Abnormalities of middle longitudinal fascicle and disorganization in patients with schizophrenia 

      Asami, Takeshi; Saito, Yukiko; Whitford, Thomas; Makris, Nikos; Niznikiewicz, Margaret A.; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Elsevier BV, 2013)
      Introduction—The Middle Longitudinal Fascicle (MdLF) is a long association fiber connecting the superior temporal gyrus (STG) and temporal pole with the angular gyrus through the white matter of the STG, structures which ...
    • Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia 

      Francis, Alan N; Seidman, Larry Joel; Jabbar, Gul A.; Mesholam-Gately, Raquelle; Thermenos, Heidi Wencel; Juelich, Richard; Proal, Ashley; Shenton, Martha Elizabeth; Kubicki, Marek R.; Mathew, Ian; Keshavan, Matcheri S; DeLisi, Lynn E (Elsevier BV, 2012)
      Introduction—Neuroanatomical and cognitive alterations typical of schizophrenia (SZ) patients are observed to a lesser extent in their adolescent and adult first-degree relatives, likely reflecting neurodevelopmental ...
    • Altered language network activity in young people at familial high-risk for schizophrenia 

      Thermenos, Heidi Wencel; Whitfield-Gabrieli, S.; Seidman, Larry Joel; Kuperberg, Gina Rosalind; Juelich, R.J.; Divatia, S.; Riley, C.; Jabbar, G.A.; Shenton, Martha Elizabeth; Kubicki, Marek R.; Manschreck, Theo Clyde; Keshavan, Matcheri S; DeLisi, Lynn E (Elsevier BV, 2013)
      Background—Abnormalities in language and language neural circuitry are observed in schizophrenia (SZ). Similar, but less pronounced language deficits are also seen in young first degree relatives of people with SZ, who ...
    • Anisotropy of transcallosal motor fibres indicates functional impairment in children with periventricular leukomalacia 

      Koerte, Inga Katharina; Pelavin, Paula; Kirmess, Berit; Fuchs, Teresa; Berweck, Steffen; Laubender, Ruediger P; Borggraefe, Ingo; Schroeder, Sebastian; Danek, Adrian; Rummeny, Caludia; Reiser, Maximilian; Kubicki, Marek R.; Shenton, Martha Elizabeth; Ertl-Wagner, Birgit; Heinen, Florian (Wiley-Blackwell, 2010)
      Aim—In children with bilateral spastic cerebral palsy (CP), periventricular leukomalacia (PVL) is commonly identified on magnetic resonance imaging. We characterized this white matter condition by examining callosal ...
    • Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study 

      Rosenberger, Gudrun; Nestor, Paul Gerard; Oh, Jungsu S.; Levitt, James Jonathan; Kindleman, Gordon; Bouix, Sylvain; Fitzsimmons, Jennifer J; Niznikiewicz, Margaret A.; Westin, Carl-Fredrik; Kikinis, Ron; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Springer Science + Business Media, 2012)
      Thalamo-cortical feedback loops play a key role in the processing and coordination of processing and integration of perceptual inputs and outputs, and disruption in this connection has long been hypothesized to contribute ...
    • The Application of DTI to Investigate White Matter Abnormalities in Schizophrenia 

      Kubicki, Marek R.; Westin, Carl-Fredrik; McCarley, Robert William; Shenton, Martha Elizabeth (Wiley-Blackwell, 2005)
      Schizophrenia is a serious and disabling mental disorder that affects approximately 1% of the general population, with often devastating effects on the psychological and financial resources of the patient, family, and ...
    • Attentional networks and cingulum bundle in chronic schizophrenia? 

      Nestor, Paul Gerard; Kubicki, Marek R.; Spencer, Kevin M.; Niznikiewicz, Margaret A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2007)
      Thirty patients with chronic schizophrenia and 30 age-matched controls performed the Attention Network Test (ANT). A subset of the patient group (n=18) also had available magnetic resonance diffusion tensor imaging (DTI) ...
    • Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia 

      Wigand, Marlene; Kubicki, Marek R.; Clemm von Hohenberg, Christian; Leicht, Gregor; Karch, Susanne; Eckbo, Ryan; Pelavin, Paula E.; Hawley, Kathryn; Rujescu, Dan; Bouix, Sylvain; Shenton, Martha Elizabeth; Mulert, Christoph (Informa UK Limited, 2014)
      Objectives—The interhemispheric auditory pathway has been shown to play a crucial role in the processing of acoustic stimuli, and alterations of structural and functional connectivity between bilateral auditory areas are ...
    • Cerebral white matter abnormalities and their associations with negative but not positive symptoms of schizophrenia 

      Asami, Takeshi; Hyuk Lee, Sang; Bouix, Sylvain; Rathi, Yogesh; Whitford, Thomas; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Elsevier BV, 2014)
      Although diffusion tensor imaging (DTI) studies have reported fractional anisotropy (FA) abnormalities in multiple white matter (WM) regions in schizophrenia, relationship between abnormal FA and negative symptoms has not ...
    • Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study 

      Kubicki, Marek R.; Westin, Carl-Fredrik; Nestor, Paul Gerard; Wible, Cynthia Gayle; Frumin, Melissa; Maier, Stephan Ernst; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2003)
      Background: Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus (CG), may play a role in the pathophysiology of schizophrenia; however, the cingulum bundle (CB), ...
    • Cingulum bundle integrity associated with delusions of control in schizophrenia: Preliminary evidence from diffusion-tensor tractography 

      Whitford, Thomas; Kubicki, Marek R.; Pelavin, Paula E.; Lucia, Diandra; Schneiderman, Jason S.; Pantelis, Christos; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2015)
      Background—Delusions of control are among the most distinctive and characteristic symptoms of schizophrenia. Several theories have been proposed that implicate aberrant communication between spatially disparate brain regions ...
    • CNTNAP2 polymorphisms and structural brain connectivity: A diffusion-tensor imaging study 

      Clemm von Hohenberg, Christian; Wigand, Marlene C.; Kubicki, Marek R.; Leicht, Gregor; Giegling, Ina; Karch, Susanne; Hartmann, Annette M.; Konte, Bettina; Friedl, Marion; Ballinger, Thomas; Eckbo, Ryan; Bouix, Sylvain; Jäger, Lorenz; Shenton, Martha Elizabeth; Rujescu, Dan; Mulert, Christoph (Elsevier BV, 2013)
      CNTNAP2 is a gene on chromosome 7 that has shown associations with autism andschizophrenia, and there is evidence that it plays an important role for neuronal synchronization and brain connectivity. In this study, we ...
    • Comparing free water imaging and magnetization transfer measurements in schizophrenia 

      Mandl, René C.W.; Pasternak, Ofer; Cahn, Wiepke; Kubicki, Marek R.; Kahn, René S.; Shenton, Martha Elizabeth; Hulshoff Pol, Hilleke E. (Elsevier BV, 2015)
      Diffusion weighted imaging (DWI) has been extensively used to study the microarchitecture of white matter in schizophrenia. However, popular DWI-derived measures such as fractional anisotropy (FA) may be sensitive to many ...
    • Comparing prefrontal gray and white matter contributions to intelligence and decision making in schizophrenia and healthy controls. 

      Nestor, Paul Gerard; Kubicki, Marek R.; Nakamura, Motoaki; Niznikiewicz, Margaret A.; McCarley, Robert William; Shenton, Martha Elizabeth (American Psychological Association (APA), 2010)
      We examined the relationship between neuropsychological performance and magnetic resonance imaging (MRI) of the orbital frontal cortex (OFC) and diffusion tensor imaging (DTI) of the cingulum bundle (CB) within groups of ...
    • Comparison of Single-Shot Echo-Planar and Line Scan Protocols for Diffusion Tensor Imaging 

      Kubicki, Marek R.; Maier, Stephan Ernst; Westin, Carl-Fredrik; Mamata, Hatsuho; Ersner-Hershfield, Hal; Estepar, Raul; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier, 2004)
      Rationale and Objectives: Both single-shot diffusion-weighted echo-planar imaging (EPI) and line scan diffusion imaging (LSDI) can be used to obtain magnetic resonance diffusion tensor data and to calculate directionally ...
    • COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder: a diffusion tensor imaging study 

      Hayashi, Kenji; Yoshimura, Reiji; Kakeda, Shingo; Kishi, Taro; Abe, Osamu; Umene-Nakano, Wakako; Katsuki, Asuka; Hori, Hikaru; Ikenouchi-Sugita, Atsuko; Watanabe, Keita; Ide, Satoru; Ueda, Issei; Moriya, Junji; Iwata, Nakao; Korogi, Yukunori; Kubicki, Marek; Nakamura, Jun (Dove Medical Press, 2014)
      We investigated the association between the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene, and white matter changes ...
    • Corpus Callosum Abnormalities and Their Association with Psychotic Symptoms in Patients with Schizophrenia 

      Whitford, Thomas; Kubicki, Marek R.; Schneiderman, Jason S.; O, Lauren J.; King, Rebecca; Alvarado, Jorge L.; Khan, Usman; Markant, Douglas; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; McCarley, Robert William; Westin, Carl-Fredrik; Shenton, Martha Elizabeth (Elsevier BV, 2010)
      Background—Whilst the neuroanatomical underpinnings of the functional brain disconnectivity observed in patients with schizophrenia remain elusive, white matter fiber bundles of the brain are a likely candidate given that ...
    • Decreased axial diffusivity within language connections: A possible biomarker of schizophrenia risk 

      Kubicki, Marek R.; Shenton, Martha Elizabeth; Maciejewski, P; Pelavin, P.E.; Hawley, K.J.; Ballinger, T.; Swisher, T.; Jabbar, G.A.; Thermenos, Heidi Wencel; Keshavan, Matcheri S; Seidman, Larry Joel; DeLisi, Lynn E (Elsevier BV, 2013)
      Siblings of patients diagnosed with schizophrenia are at elevated risk for developing this disorder. The nature of such risk associated with brain abnormalities, and whether such abnormalities are similar to those observed ...
    • Diffusion Tensor Imaging and Its Application to Neuropsychiatric Disorders 

      Kubicki, Marek R.; Westin, Carl-Fredrik; Maier, Stephan Ernst; Mamata, Hatsuho; Frumin, Melissa; Ersner-Hershfield, Hal; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Ovid Technologies (Wolters Kluwer Health), 2002)
      Magnetic resonance diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue; it is particularly useful for evaluating white matter abnormalities. ...