Now showing items 1-2 of 2

    • Deletion of Prepl Causes Growth Impairment and Hypotonia in Mice 

      Lone, Anna Mari; Leidl, Mathias; McFedries, Amanda K.; Horner, James W.; Creemers, John; Saghatelian, Alan (Public Library of Science, 2014)
      Genetic studies of rare diseases can identify genes of unknown function that strongly impact human physiology. Prolyl endopeptidase-like (PREPL) is an uncharacterized member of the prolyl peptidase family that was discovered ...
    • A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid utilization 

      Liu, Sihao; Brown, Jonathan D.; Stanya, Kristopher J.; Homan, Edwin; Leidl, Mathias; Inouye, Karen; Bhargava, Prerna; Gangl, Matthew R.; Dai, Lingling; Hatano, Ben; Hotamisligil, Gökhan S.; Saghatelian, Alan; Plutzky, Jorge; Lee, Chih-Hao (2014)
      Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage or utilization. In mice, this program follows a circadian rhythm that peaks with nocturnal ...