Now showing items 1-10 of 10

    • Cognitive remediation versus active computer control in bipolar disorder with psychosis: study protocol for a randomized controlled trial 

      Lewandowski, Kathryn Eve; Sperry, Sarah H.; Ongur, Dost; Cohen, Bruce M.; Norris, Lesley A.; Keshavan, Matcheri S. (BioMed Central, 2016)
      Background: Cognitive dysfunction is a major feature of bipolar disorder with psychosis and is strongly associated with functional outcomes. Computer-based cognitive remediation has shown promise in improving cognition in ...
    • Cognitive Vulnerability to Major Depression: View from the Intrinsic Network and Cross-network Interactions 

      Wang, Xiang; Öngür, Dost; Auerbach, Randy P.; Yao, Shuqiao (Lippincott Williams & Wilkins, 2016)
      Abstract Although it is generally accepted that cognitive factors contribute to the pathogenesis of major depressive disorder (MDD), there are missing links between behavioral and biological models of depression. Nevertheless, ...
    • Deficient biological motion perception in schizophrenia: results from a motion noise paradigm 

      Kim, Jejoong; Norton, Daniel; McBain, Ryan; Ongur, Dost; Chen, Yue (Frontiers Media S.A., 2013)
      Background:: Schizophrenia patients exhibit deficient processing of perceptual and cognitive information. However, it is not well-understood how basic perceptual deficits contribute to higher level cognitive problems in ...
    • Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons 

      Yoshimizu, Takao; Pan, Jen Q.; Mungenast, Alison E.; Madison, Jon M.; Su, Susan; Ketterman, Josh; Ongur, Dost; McPhie, Donna; Cohen, Bruce; Perlis, Roy; Tsai, Li-Huei (2014)
      Psychiatric disorders have clear heritable risk. Several large-scale genome-wide association studies have revealed a strong association between susceptibility for psychiatric disorders, including bipolar disease, schizophrenia, ...
    • Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis 

      Zhang, Bei; Lin, Pan; Shi, Huqing; Öngür, Dost; Auerbach, Randy P.; Wang, Xiaosheng; Yao, Shuqiao; Wang, Xiang (Springer US, 2015)
      Anhedonia is a prominent symptom in neuropsychiatric disorders, most markedly in major depressive disorder (MDD) and schizophrenia (SZ). Emerging evidence indicates an overlap in the neural substrates of anhedonia between ...
    • Pathway Analyses Implicate Glial Cells in Schizophrenia 

      Duncan, Laramie E.; Holmans, Peter A.; Lee, Phil H.; O'Dushlaine, Colm T.; Kirby, Andrew W.; Smoller, Jordan W.; Öngür, Dost; Cohen, Bruce M. (Public Library of Science, 2014)
      Background: The quest to understand the neurobiology of schizophrenia and bipolar disorder is ongoing with multiple lines of evidence indicating abnormalities of glia, mitochondria, and glutamate in both disorders. Despite ...
    • Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques 

      Du, Fei; Ongur, Dost (Frontiers Media S.A., 2013)
      In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements ...
    • Religious coping among psychotic patients: Relevance to suicidality and treatment outcomes 

      Rosmarin, David Hillel; Bigda-Peyton, Joseph S.; Ongur, Dost; Pargament, Kenneth I.; Bjorgvinsson, Throstur (Elsevier BV, 2013)
      Religious coping is very common among individuals with psychosis, however its relevance to symptoms and treatment outcomes remains unclear. We conducted a prospective study in a clinical sample of n1⁄447 psychiatric patients ...
    • Reward Learning, Neurocognition, Social Cognition, and Symptomatology in Psychosis 

      Lewandowski, Kathryn E.; Whitton, Alexis E.; Pizzagalli, Diego A.; Norris, Lesley A.; Ongur, Dost; Hall, Mei-Hua (Frontiers Media S.A., 2016)
      Background: Patients with psychosis spectrum disorders exhibit deficits in social and neurocognition, as well as hallmark abnormalities in motivation and reward processing. Aspects of reward processing may overlap behaviorally ...
    • Sprouty2 in the Dorsal Hippocampus Regulates Neurogenesis and Stress Responsiveness in Rats 

      Dow, Antonia L.; Lin, Tiffany V.; Chartoff, Elena H.; Potter, David; McPhie, Donna L.; Van’t Veer, Ashlee V.; Knoll, Allison T.; Lee, Kristen N.; Neve, Rachael L.; Patel, Tarun B.; Ongur, Dost; Cohen, Bruce M.; Carlezon, William A. (Public Library of Science, 2015)
      Both the development and relief of stress-related psychiatric conditions such as major depression (MD) and post-traumatic stress disorder (PTSD) have been linked to neuroplastic changes in the brain. One such change involves ...