Now showing items 1-2 of 2

    • Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death 

      Albeck, John Gerald; Burke, John M.; Spencer, Sabrina Leigh; Lauffenburger, Douglas A.; Sorger, Peter Karl (Public Library of Science, 2008)
      When exposed to tumor necrosis factor (TNF) or TNF-related apoptosis-inducing ligand (TRAIL), a closely related death ligand and investigational therapeutic, cells enter a protracted period of variable duration in which ...
    • Systemic Calibration of a Cell Signaling Network Model 

      Spencer, Sabrina Leigh; Albeck, John Gerald; Burke, John M.; Sorger, Peter Karl; Gaudet, Suzanne; Kim, Kyoung Ae; Kim, Do Hyun (BioMed Central, 2010)
      Background: Mathematical modeling is being applied to increasingly complex biological systems and datasets; however, the process of analyzing and calibrating against experimental data is often challenging and a rate limiting ...