Browsing by Author "Roh, Mi In"
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Evidence for Baseline Retinal Pigment Epithelium Pathology in the Trp1-Cre Mouse
Thanos, Aristomenis; Morizane, Yuki; Murakami, Yusuke; Giani, Andrea; Mantopoulos, Dimosthenis; Kayama, Maki; Roh, Mi In; Michaud, Norman; Pawlyk, Basil; Sandberg, Michael Arthur; Young, Lucy Hwa-Yue; Miller, Joan Whitten; Vavvas, Demetrios (Elsevier BV, 2012)The increasing popularity of the Cre/loxP recombination system has led to the generation of numerous transgenic mouse lines in which Cre recombinase is expressed under the control of organ- or cell-specific promoters. ... -
Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration
Murakami, Y; Matsumoto, Hidetaka; Roh, Mi In; Giani, A; Kataoka, Keiko; Morizane, Y; Kayama, M; Thanos, Aristomenis; Nakatake, S; Notomi, S; Hisatomi, T; Ikeda, Y; Ishibashi, T; Connor, K M; Miller, Joan Whitten; Vavvas, Demetrios (Springer Nature, 2013)There is no known treatment for the dry form of an age-related macular degeneration (AMD). Cell death and inflammation are important biological processes thought to have central role in AMD. Here we show that receptor-interacting ... -
Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration
Murakami, Y.; Matsumoto, Hidetaka; Roh, Mi In; Suzuki, J.; Hisatomi, T.; Ikeda, Y.; Miller, Joan Whitten; Vavvas, Demetrios (Proceedings of the National Academy of Sciences, 2012)Retinitis pigmentosa comprises a group of inherited retinal photoreceptor degenerations that lead to progressive loss of vision. Although in most cases rods, but not cones, harbor the deleterious gene mutations, cones do ... -
Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization
Salehi-Had, Hani; Roh, Mi In; Giani, Andrea; Hisatomi, Toshio; Nakao, Shintaro; Kim, Ivana Kyung; Gragoudas, Evangelos Stelios; Vavvas, Demetrios; Guccione, Samira; Miller, Joan Whitten (Public Library of Science, 2011)Purpose: The integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular ...