Browsing by Author "Lemere, Cynthia"
Now showing items 1-8 of 8
-
Antibody Engineering & Therapeutics 2016: The Antibody Society's annual meeting, December 11–15, 2016, San Diego, CA
Larrick, James W.; Alfenito, Mark R.; Scott, Jamie K.; Parren, Paul W. H. I.; Burton, Dennis R.; Bradbury, Andrew R. M.; Lemere, Cynthia A.; Messer, Anne; Huston, James S.; Carter, Paul J.; Veldman, Trudi; Chester, Kerry A.; Schuurman, Janine; Adams, Gregory P.; Reichert, Janice M. (Taylor & Francis, 2016)ABSTRACT Antibody Engineering & Therapeutics, the largest meeting devoted to antibody science and technology and the annual meeting of The Antibody Society, will be held in San Diego, CA on December 11-15, 2016. Each of ... -
Boosting with Intranasal Dendrimeric Aβ1–15 but Not Aβ1–15 Peptide Leads to an Effective Immune Response Following a Single Injection of Aβ1–40/42 in APP-tg Mice
Seabrook, Timothy J; Jiang, Liying; Thomas, Katelyn; Lemere, Cynthia Ann (BioMed Central, 2006)Background: Immunotherapy for Alzheimer's disease (AD) is emerging as a potential treatment. However, a clinical trial (AN1792) was halted after adverse effects occurred in a small subset of subjects, which may have been ... -
Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo
An, Kyongman; Klyubin, Igor; Kim, Youngkyu; Jung, Jung Hoon; Mably, Alexandra J; O’Dowd, Sean T; Lynch, Timothy; Kanmert, Daniel; Lemere, Cynthia A; Finan, Gina M; Park, Joon Won; Kim, Tae-Wan; Walsh, Dominic M; Rowan, Michael J; Kim, Joung-Hun (BioMed Central, 2013)Background: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer’s disease (AD)-associated amyloid β-protein (Aβ). Despite their ... -
Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer’s Disease
Cherry, Jonathan D.; Liu, Bin; Frost, Jeffrey L.; Lemere, Cynthia Ann; Williams, Jacqueline P.; Olschowka, John A.; O’Banion, M. Kerry (Public Library of Science, 2012)Galactic Cosmic Radiation consisting of high-energy, high-charged (HZE) particles poses a significant threat to future astronauts in deep space. Aside from cancer, concerns have been raised about late degenerative risks, ... -
Immunotherapy for Alzheimer’s disease: hoops and hurdles
Lemere, Cynthia A (BioMed Central, 2013)Alzheimer’s disease (AD) is the most common form of dementia, afflicting more than 30 million people worldwide. Currently, there is no cure or way to prevent this devastating disease. Extracellular plaques, containing ... -
Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges
Cynis, Holger; Frost, Jeffrey L.; Crehan, Helen; Lemere, Cynthia A. (BioMed Central, 2016)Immunization against amyloid-β (Aβ) peptides deposited in Alzheimer’s disease (AD) has shown considerable therapeutic effect in animal models however, the translation into human Alzheimer’s patients is challenging. In ... -
Osteopetrotic (op/op) Mice Have Reduced Microglia, No Aβ Deposition, and No Changes in Dopaminergic Neurons
Kondo, Yoichi; Lemere, Cynthia Ann; Seabrook, Timothy J (BioMed Central, 2007)Background: Activation of microglia is a part of the inflammatory response in neurodegenerative diseases but its role in the pathophysiology of these diseases is still unclear. The osteopetrotic (op/op) mouse lacks ... -
Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study
Frost, Jeffrey L.; Liu, Bin; Kleinschmidt, Martin; Schilling, Stephan; Demuth, Hans-Ulrich; Lemere, Cynthia A. (S. Karger AG, 2012)Background: N-terminally truncated and modified pyroglutamate-3 amyloid-β protein (pE3-Aβ) is present in most, if not all, cerebral plaque and vascular amyloid deposits in human Alzheimer's disease (AD). pE3-Aβ deposition ...