Now showing items 1-12 of 12

    • Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys 

      Chan, Tiffany; O'Brien, Kara L.; Goldstein, David B.; Haynes, Barton F.; Malik, Harmit S.; Lim, So-Yon; Gelman, Rebecca Sue; Whitney, James B.; Barouch, Dan Hung; Letvin, Norman Lee (Public Library of Science, 2010)
      CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 ...
    • Genital Tract Sequestration of SIV following Acute Infection 

      Whitney, James B.; Hraber, Peter T.; Luedemann, Corinne; Giorgi, Elena E.; Daniels, Marcus G.; Bhattacharya, Tanmoy; Rao, Srinivas S.; Mascola, John R.; Nabel, Gary J.; Korber, Bette T.; Letvin, Norman Lee (Public Library of Science, 2011)
      We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. ...
    • Impaired RNA Incorporation and Dimerization in Live Attenuated Leader-variants of SIVmac239 

      Whitney, James B.; Wainberg, Mark A (BioMed Central, 2006)
      Background: The 5' untranslated region (UTR) or leader sequence of simian immunodeficiency virus (SIVmac239) is multifunctional and harbors the regulatory elements for viral replication, persistence, gene translation, ...
    • In Vivo Anti-HIV Activity of the Heparin-Activated Serine Protease Inhibitor Antithrombin III Encapsulated in Lymph-Targeting Immunoliposomes 

      Asmal, Mohammed; Whitney, James B.; Luedemann, Corinne; Carville, Angela; Steen, Robert G.; Letvin, Norman L.; Geiben-Lynn, Ralf (Public Library of Science, 2012)
      Endogenous serine protease inhibitors (serpins) are anti-inflammatory mediators with multiple biologic functions. Several serpins have been reported to modulate HIV pathogenesis, or exhibit potent anti-HIV activity in ...
    • P03-07. Autologous Neutralizing Antibodies That Select Viral Escape Variants Emerge Late After SIV Infection of Rhesus Monkeys 

      Rahman, I; Hraber, P; Giri, A; Nevidomskyte, D; Coffey, RT; Miljkovic, S; Keele, BF; Shaw, GM; Korber, BT; Yeh, Wendy Wen-Li; Asmal, Mohammed; Whitney, James B.; Seaman, Michael S.; Letvin, Norman Lee (BioMed Central, 2009)
    • P04-41. Kinetics of Antibody Neutralization and Viral Evolution Following Envelope Vaccination in SIV-infected Rhesus Monkeys 

      Basavapathruni, A; Coffey, R; Hraber, P; Giri, A; Mascola, J; Nabel, G; Korber, B; Yeh, Wendy Wen-Li; Whitney, James B.; Rao, Sowmya R.; Seaman, Michael S.; Letvin, Norman Lee (BioMed Central, 2009)
      Poster presentation. Conclusion: Our results indicate that env vaccination is associated with an accelerated development of autologous neutralizing antibodies. These antibodies were focused at least in part on the V1 region ...
    • Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences 

      Tartaglia, Lawrence J.; Chang, Hui-Wen; Lee, Benjamin C.; Abbink, Peter; Ng’ang’a, David; Boyd, Michael; Lavine, Christy L.; Lim, So-Yon; Sanisetty, Srisowmya; Whitney, James B.; Seaman, Michael S.; Rolland, Morgane; Tovanabutra, Sodsai; Ananworanich, Jintanat; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.; Barouch, Dan H. (Public Library of Science, 2016)
      Simian-human immunodeficiency virus (SHIV) challenge stocks are critical for preclinical testing of vaccines, antibodies, and other interventions aimed to prevent HIV-1. A major unmet need for the field has been the lack ...
    • Rapid Seeding of the Viral Reservoir Prior to SIV Viremia in Rhesus Monkeys 

      Whitney, James B.; Hill, Alison L.; Sanisetty, Srisowmya; Penaloza-MacMaster, Pablo; Liu, Jinyan; Shetty, Mayuri; Parenteau, Lily; Cabral, Crystal; Shields, Jennifer; Blackmore, Stephen; Smith, Jeffrey Y.; Brinkman, Amanda L.; Peter, Lauren E.; Mathew, Sheeba I.; Smith, Kaitlin M.; Borducchi, Erica N.; Rosenbloom, Daniel I.S.; Lewis, Mark G.; Hattersley, Jillian; Li, Bei; Hesselgesser, Joseph; Geleziunas, Romas; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.; Barouch, Dan H. (2014)
      The viral reservoir represents a critical challenge facing HIV-1 eradication strategies1–5. However, it remains unclear when and where the viral reservoir is seeded during acute infection and the extent to which it is ...
    • Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genome 

      Whitney, James B.; Wainberg, Mark A (BioMed Central, 2007)
      We have analyzed a SIV deletion mutant that was compromised both in viral replication and RNA packaging. Serial passage of this variant in two different T-cell lines resulted in compensatory reversion and the generation ...
    • Serpin Induced Antiviral Activity of Prostaglandin Synthetase-2 Against HIV-1 Replication 

      Whitney, James B.; Asmal, Mohammed; Geiben-Lynn, Ralf (Public Library of Science, 2011)
      The serine protease inhibitors (serpins) are anti-inflammatory proteins that have various functions. By screening a diverse panel of viruses, we demonstrate that the serpin antithrombin III (ATIII) has a broad-spectrum ...
    • A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes 

      Jones, R. Brad; Mueller, Stefanie; O’Connor, Rachel; Rimpel, Katherine; Sloan, Derek D.; Karel, Dan; Wong, Hing C.; Jeng, Emily K.; Thomas, Allison S.; Whitney, James B.; Lim, So-Yon; Kovacs, Colin; Benko, Erika; Karandish, Sara; Huang, Szu-Han; Buzon, Maria J.; Lichterfeld, Mathias; Irrinki, Alivelu; Murry, Jeffrey P.; Tsai, Angela; Yu, Helen; Geleziunas, Romas; Trocha, Alicja; Ostrowski, Mario A.; Irvine, Darrell J.; Walker, Bruce D. (Public Library of Science, 2016)
      Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic ...
    • Therapeutic Efficacy of Potent Neutralizing HIV-1-Specific Monoclonal Antibodies in SHIV-Infected Rhesus Monkeys 

      Barouch, Dan H.; Whitney, James B.; Moldt, Brian; Klein, Florian; Oliveira, Thiago Y.; Liu, Jinyan; Stephenson, Kathryn E.; Chang, Hui-Wen; Shekhar, Karthik; Gupta, Sanjana; Nkolola, Joseph P.; Seaman, Michael S.; Smith, Kaitlin M.; Borducchi, Erica N.; Cabral, Crystal; Smith, Jeffrey Y.; Blackmore, Stephen; Sanisetty, Srisowmya; Perry, James R.; Beck, Matthew; Lewis, Mark G.; Rinaldi, William; Chakraborty, Arup K.; Poignard, Pascal; Nussenzweig, Michel C.; Burton, Dennis R. (2014)
      HIV-1-specific monoclonal antibodies (mAbs) with extraordinary potency and breadth have recently been described. In humanized mice, combinations of mAbs have been shown to suppress viremia, but the therapeutic potential ...