Now showing items 1-3 of 3

    • An Epigenetic Blockade of Cognitive Functions in the Neurodegenerating Brain 

      Gräff, Johannes; Rei, Damien; Guan, Ji-Song; Wang, Wen-Yuan; Seo, Jinsoo; Fass, Daniel M.; Kao, Patricia F.; Kahn, Martin; Su, Susan C.; Joseph, Nadine; Delalle, Ivana; Tsai, Li-Huei; Hennig, Krista M.; Nieland, Thomas; Samiei, Alireza; Haggarty, Stephen John (Nature Publishing Group, 2012)
      Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central nervous system, including Alzheimer’s disease. The causes leading to such impairment are only poorly understood and effective ...
    • HDAC2 Negatively Regulates Memory Formation and Synaptic Plasticity 

      Guan, Ji-Song; Giacometti, Emanuela; Dannenberg, Jan-Hermen; Joseph, Nadine; Gao, Jun; DePinho, Ronald A.; Jaenisch, Rudolf; Tsai, Li-Huei; Haggarty, Stephen John; Nieland, Thomas; Zhou, Ying; Wang, Xinyu; Mazitschek, Ralph; Bradner, James Elliott (Nature Publishing Group, 2012)
      Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation. Increased histone-tail acetylation induced by inhibitors of histone deacetylases (HDACis) facilitates learning and ...
    • High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons 

      Nieland, Thomas J. F.; Logan, David J.; Saulnier, Jessica; Lam, Daniel; Johnson, Caroline; Root, David E.; Carpenter, Anne E.; Sabatini, Bernardo L. (Public Library of Science, 2014)
      The formation of synapses, the specialized points of chemical communication between neurons, is a highly regulated developmental process fundamental to establishing normal brain circuitry. Perturbations of synapse formation ...