Now showing items 1-4 of 4

    • The aged niche disrupts muscle stem cell quiescence 

      Chakkalakal, Joe V.; Jones, Kieran M.; Basson, M. Albert; Brack, Andrew Stephen (2012)
      SUMMARY The niche is a conserved regulator of stem cell quiescence and function. During aging, stem cell function declines. To what extent and by which means age-related changes within the niche contribute to this phenomenon ...
    • Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA 

      Warren, Luigi; Manos, Philip D.; Ahfeldt, Tim; Loh, Yuin-Han; Li, Hu; Lau, Frank; Ebina, Wataru; Mandal, Pankaj Kumar; Smith, Zachary D; Meissner, Alexander; Daley, George Quentin; Brack, Andrew Stephen; Collins, James J.; Cowan, Chad A.; Schlaeger, Thorsten M.; Rossi, Derrick J (Elsevier BV, 2010)
      Clinical application of induced pluripotent stem cells (iPSCs) is limited by the low efficiency of iPSC derivation and the fact that most protocols modify the genome to effect cellular reprogramming. Moreover, safe and ...
    • Lineage of origin in rhabdomyosarcoma informs pharmacological response 

      Abraham, Jacob; Nunez-Alvarez, Y.; Hettmer, S; Carrio, E.; Chen, Hung-I Harry; Nishijo, K.; Huang, Elaine; Prajapati, Suresh I.; Walker, Robert L.; Davis, Sean; Rebeles, Jennifer; Wiebush, Hunter; McCleish, Amanda T.; Hampton, Sheila T.; Bjornson, Christopher R.R.; Brack, Andrew Stephen; Wagers, Amy Jo; Rando, Thomas A.; Capecchi, Mario R.; Marini, Frank C.; Ehler, Benjamin R.; Zarzabal, Lee Ann; Goros, Martin W.; Michalek, Joel E.; Meltzer, Paul S.; Langenau, David M.; LeGallo, Robin D.; Mansoor, Asif Imran; Chen, Yidong; Suelves, Monica; Rubin, Brian P.; Keller, Charles (Cold Spring Harbor Laboratory Press, 2014)
      Lineage or cell of origin of cancers is often unknown and thus is not a consideration in therapeutic approaches. Alveolar rhabdomyosarcoma (aRMS) is an aggressive childhood cancer for which the cell of origin remains ...
    • Pax7 is back 

      Brack, Andrew S (BioMed Central, 2014)
      Two recent studies have reinvigorated the conversation regarding the role of Pax7 in adult satellite. Studies by Gunther et al (Cell Stem Cell 13:590–601, 2013) and Von Maltzhen et al (Proc Natl Acad Sci U S A 110:16474–16479) ...