Now showing items 1-8 of 8

    • Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation 

      O'Rourke, Caitlin; Shelton, Georgia; Hutcheson, Joshua; Burke, Megan F.; Martyn, Trejeeve; Thayer, Timothy E.; Shakartzi, Hannah R.; Buswell, Mary D.; Tainsh, Robert; Yu, Binglan; Bagchi, Aranya; Rhee, David Kwan; Wu, Connie; Derwall, Matthias; Buys, Emmanuel; Yu, Paul B.; Bloch, Kenneth; Aikawa, Elena; Bloch, Donald Bendit; Malhotra, Rajeev (MyJove Corporation, 2016)
      Cardiovascular disease is the leading cause of morbidity and mortality in the world. Atherosclerotic plaques, consisting of lipid-laden macrophages and calcification, develop in the coronary arteries, aortic valve, aorta, ...
    • Genetic modifiers of hypertension in soluble guanylate cyclase α1–deficient mice 

      Buys, Emmanuel; Raher, Michael J.; Kirby, Andrew; Mohd, Shahid; Baron, David William; Hayton, Sarah R.; Tainsh, Laurel T.; Sips, Patrick; Rauwerdink, Kristen M.; Yan, Qingshang; Tainsh, Robert E; Shakartzi, Hannah R.; Stevens, Christine; Decaluwé, Kelly; Rodrigues-Machado, Maria da Gloria; Malhotra, Rajeev; Van de Voorde, Johan; Wang, Tong; Brouckaert, Peter; Daly, Mark Joseph; Bloch, Kenneth Daniel (American Society for Clinical Investigation, 2012)
      Nitric oxide (NO) plays an essential role in regulating hypertension and blood flow by inducing relaxation of vascular smooth muscle. Male mice deficient in a NO receptor component, the α1 subunit of soluble guanylate ...
    • Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency 

      Malhotra, Rajeev; Burke, Megan F.; Martyn, Trejeeve; Shakartzi, Hannah R.; Thayer, Timothy E.; O’Rourke, Caitlin; Li, Pingcheng; Derwall, Matthias; Spagnolli, Ester; Kolodziej, Starsha A.; Hoeft, Konrad; Mayeur, Claire; Jiramongkolchai, Pawina; Kumar, Ravindra; Buys, Emmanuel S.; Yu, Paul B.; Bloch, Kenneth D.; Bloch, Donald B. (Public Library of Science, 2015)
      Objective: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both ...
    • LMKB/MARF1 Localizes to mRNA Processing Bodies, Interacts with Ge-1, and Regulates IFI44L Gene Expression 

      Bloch, Donald B.; Li, Pingcheng; Bloch, Emily G.; Berenson, Daniel F.; Galdos, Rita L.; Arora, Pankaj; Malhotra, Rajeev; Wu, Connie; Yang, Weihong (Public Library of Science, 2014)
      The mRNA processing body (P-body) is a cellular structure that regulates the stability of cytoplasmic mRNA. MARF1 is a murine oocyte RNA-binding protein that is associated with maintenance of mRNA homeostasis and genomic ...
    • Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene 

      Steinbicker, Andrea U.; Liu, Heling; Jiramongkolchai, Kim; Malhotra, Rajeev; Choe, Elizabeth Y.; Busch, Cornelius J.; Graveline, Amanda R; Kao, Sonya M.; Nagasaka, Yasuko; Ichinose, Fumito; Buys, Emmanuel; Brouckaert, Peter; Zapol, Warren Myron; Bloch, Kenneth Daniel (Elsevier BV, 2011)
      Nitric oxide (NO) regulates vascular smooth muscle cell (VSMC) structure and function, in part by activating soluble guanylate cyclase (sGC) to synthesize cGMP. The objective of this study was to further characterize the ...
    • An open-source computational tool to automatically quantify immunolabeled retinal ganglion cells 

      Dordea, Ana; Bray, Mark-Anthony; Allen, Kaitlin; Logan, David J.; Fei, Fei; Malhotra, Rajeev; Gregory, Meredith; Carpenter, Anne E.; Buys, Emmanuel (Elsevier BV, 2016)
      A fully automated and robust method was developed to quantify b-III-tubulin-stained retinal ganglion cells, combining computational recognition of individual cells by CellProfiler and a machine-learning tool to teach ...
    • Soluble Guanylate Cyclase  1 1 Limits Stroke Size and Attenuates Neurological Injury 

      Atochin, Dmitriy N.; Yuzawa, Izumi; Li, Qian; Rauwerdink, Kristen M.; Malhotra, Rajeev; Chang, Junlei; Brouckaert, Peter; Ayata, Cenk; Moskowitz, Michael Arthur; Bloch, Kenneth Daniel; Huang, Paul Lee; Buys, Emmanuel (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background and Purpose— Nitric oxide mediates endothelium-dependent vasodilation, modulates cerebral blood flow, and determines stroke outcome. Nitric oxide signals in part by stimulating soluble guanylate cyclase (sGC) ...
    • Soluble Guanylate Cyclase α1–Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma 

      Ko, Yu-Chieh; Hayton, Sarah R.; Jones, Alexander; Tainsh, Laurel T.; Ren, Ruiyi; Giani, Andrea; Clerté, Maeva; Abernathy, Emma; de Waard, Nadine; Turcotte, Raphael; Nathan, Daniel; Loomis, Stephanie J.; Gong, Haiyan; Brouckaert, Peter; Buys, Emmanuel; Alt, Clemens; Tainsh, Robert Edward Tillinghast; Oh, Dong-Jin; Malhotra, Rajeev; Arora, Pankaj; Yu, Binglan; Scherrer-Crosbie, Marielle; Kang, Jae Hee Hee; Lin, Charles P.; Rhee, Douglas J; Wiggs, Janey Lee; Gregory, Meredith S.; Pasquale, Louis; Bloch, Kenneth Daniel; Ksander, Bruce R. (Public Library of Science, 2013)
      Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the \(α_1\) subunit of the nitric ...