Now showing items 1-17 of 17

    • Abnormal Neural Synchrony in Schizophrenia 

      Spencer, Kevin M.; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; Salisbury, Dean F.; Shenton, Martha Elizabeth; McCarley, Robert William (2003)
      Schizophrenia has been conceptualized as a failure of cognitive integration, and abnormalities in neural circuitry (particularly inhibitory interneurons) have been proposed as a basis for this disorder. We used measures ...
    • Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder 

      Niznikiewicz, Margaret A.; Spencer, Kevin M.; Dickey, Chandlee C.; Voglmaier, Martina M.; Seidman, Larry Joel; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2009)
      Background: The goal of the study was to examine mismatch negativity (MMN) in schizotypal personality disorder (SPD) individuals. Abnormal MMN has been a consistent finding in chronic schizophrenia and there are also have ...
    • Attentional Load Effects on Beta Oscillations in Healthy and Schizophrenic Individuals 

      Ghorashi, Shahab; Spencer, Kevin M. (Frontiers Media S.A., 2015)
      Attentional deficits are prominent among the cognitive disturbances found in schizophrenia. Given that schizophrenia is also characterized by abnormalities in high-frequency oscillations, we investigated whether attentional ...
    • Attentional networks and cingulum bundle in chronic schizophrenia? 

      Nestor, Paul Gerard; Kubicki, Marek R.; Spencer, Kevin M.; Niznikiewicz, Margaret A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2007)
      Thirty patients with chronic schizophrenia and 30 age-matched controls performed the Attention Network Test (ANT). A subset of the patient group (n=18) also had available magnetic resonance diffusion tensor imaging (DTI) ...
    • Baseline Gamma Power during Auditory Steady-State Stimulation in Schizophrenia 

      Spencer, Kevin M. (Frontiers Research Foundation, 2012)
      Several studies have reported deficits in \(\gamma\) oscillatory activity elicited by sensory stimulation or cognitive processes in schizophrenia patients (SZ) compared to healthy control subjects (HC). However, the evidence ...
    • Clinical high risk and first episode schizophrenia: Auditory event-related potentials 

      Del Re, Elisabetta; Spencer, Kevin M.; Oribe, Naoya; Mesholam-Gately, Raquelle; Goldstein, Jill M.; Shenton, Martha Elizabeth; Petryshen, Tracey Lynn; Seidman, Larry Joel; McCarley, Robert William; Niznikiewicz, Margaret A. (Elsevier BV, 2015)
      The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with ...
    • Functional and Structural Deficits in Brain Regions Subserving Face Perception in Schizophrenia 

      Onitsuka, Toshiaki; Niznikiewicz, Margaret A.; Spencer, Kevin M.; Frumin, Melissa; Kuroki, Noriomi; Lucia, Lisa C.; Shenton, Martha Elizabeth; McCarley, Robert William (American Psychiatric Publishing, 2006)
      Objective: Schizophrenia impairs many cognitive functions, including face perception. Veridical face perception is critical for social interaction, including distinguishing friend from foe and familiar from unfamiliar ...
    • The Functional Consequences of Cortical Circuit Abnormalities on Gamma Oscillations in Schizophrenia: Insights from Computational Modeling 

      Spencer, Kevin M. (Frontiers Research Foundation, 2009)
      Schizophrenia is characterized by cortical circuit abnormalities, which might be reflected in γ-frequency (30–100 Hz) oscillations in the electroencephalogram. Here we used a computational model of cortical circuitry to ...
    • Gamma-Band Auditory Steady-State Responses Are Impaired in First Episode Psychosis 

      Spencer, Kevin M.; Salisbury, Dean F.; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2008)
      Background: In chronic schizophrenia and chronic bipolar disorder, gamma band (30–100 Hz) auditory steady-state EEG responses (ASSRs) are reduced in power and phase locking, likely reflecting neural circuit dysfunction. ...
    • Hemispheric Biases and the Control of Visuospatial Attention: An ERP Study 

      Spencer, Kevin M.; Banich, Marie T (BioMed Central, 2005)
      Background: We examined whether individual differences in hemispheric utilization can interact with the intrinsic attentional biases of the cerebral hemispheres. Evidence suggests that the hemispheres have competing biases ...
    • Left Auditory Cortex Gamma Synchronization and Auditory Hallucination Symptoms in Schizophrenia 

      Spencer, Kevin M.; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; Shenton, Martha E.; McCarley, Robert William (BioMed Central, 2009)
      Background: Oscillatory electroencephalogram (EEG) abnormalities may reflect neural circuit dysfunction in neuropsychiatric disorders. Previously we have found positive correlations between the phase synchronization of ...
    • Neural synchrony indexes disordered perception and cognition in schizophrenia 

      Spencer, Kevin M.; Nestor, Paul Gerard; Perlmutter, R.; Niznikiewicz, Margaret A.; Klump, M. C.; Frumin, Melissa; Shenton, Martha Elizabeth; McCarley, Robert William (Proceedings of the National Academy of Sciences, 2004)
      Current views of schizophrenia suggest that it results from abnormalities in neural circuitry, but empirical evidence in the millisecond range of neural activity has been difficult to obtain. In pursuit of relevant evidence, ...
    • Oscillatory dynamics of Gestalt perception in schizophrenia revisited 

      Spencer, Kevin M.; Ghorashi, Shahab (Frontiers Media S.A., 2014)
      Background: Abnormalities in γ oscillations (30–100 Hz) in the scalp-recorded electroencephalogram (EEG) have been proposed to reflect neural circuitry abnormalities in schizophrenia. Oscillations in the γ band are thought ...
    • Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: A combined ERP and DTI study 

      Whitford, Thomas; Kubicki, Marek R.; Ghorashi, Shahab; Schneiderman, Jason S.; Hawley, Kathryn J.; McCarley, Robert William; Shenton, Martha Elizabeth; Spencer, Kevin M. (Elsevier BV, 2011)
      Background—Several theories of schizophrenia have emphasized the role of aberrant neural timing in the etiology of the disease, possibly as a consequence of conduction delays caused by structural damage to the white-matter ...
    • Semantic disturbance in schizophrenia and its relationship to the cognitive neuroscience of attention 

      Nestor, Paul Gerard; Han, S.D; Niznikiewicz, Margaret A.; Salisbury, D; Spencer, Kevin M.; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2001)
      We view schizophrenia as producing a failure of attentional modulation that leads to a breakdown in the selective enhancement or inhibition of semantic/lexical representations whose biological substrata are widely distributed ...
    • Sensory-Evoked Gamma Oscillations in Chronic Schizophrenia 

      Spencer, Kevin M.; Niznikiewicz, Margaret A.; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2008)
      Background: The early visual-evoked gamma oscillation (VGO) elicited by Gestalt stimuli is reduced in schizophrenia patients compared to healthy individuals, but it is unknown whether this effect is specific to these ...
    • Word priming in schizophrenia: Associational and semantic influences 

      Nestor, Paul Gerard; Valdman, Olga; Niznikiewicz, Margaret A.; Spencer, Kevin M.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2006)
      We examined semantic vs. associational influences on word priming in schizophrenia. Tested on three occasions, subjects made speeded lexical decisions to three kinds of prime-word relationships: semantic-only (e.g., ...