Now showing items 1-20 of 39

    • Beneficial and perverse effects of isoniazid preventive therapy for latent tuberculosis infection in HIV-tuberculosis coinfected populations 

      Cohen, Theodore H.; Lipsitch, Marc; Walensky, Rochelle P.; Murray, Megan Blanche (Proceedings of the National Academy of Sciences, 2006)
      In sub-Saharan Africa, where the emergence of HIV has caused dramatic increases in tuberculosis (TB) case notifications, new strategies for TB control are necessary. Isoniazid preventive therapy (IPT) for HIV-TB coinfected ...
    • The Clinical and Economic Impact of Point-of-Care CD4 Testing in Mozambique and Other Resource-Limited Settings: A Cost-Effectiveness Analysis 

      Hyle, Emily P.; Jani, Ilesh V.; Lehe, Jonathan; Su, Amanda E.; Wood, Robin; Quevedo, Jorge; Losina, Elena; Bassett, Ingrid V.; Pei, Pamela P.; Paltiel, A. David; Resch, Stephen; Freedberg, Kenneth A.; Peter, Trevor; Walensky, Rochelle P. (Public Library of Science, 2014)
      Background: Point-of-care CD4 tests at HIV diagnosis could improve linkage to care in resource-limited settings. Our objective is to evaluate the clinical and economic impact of point-of-care CD4 tests compared to ...
    • Clinical Impact and Cost-Effectiveness of Expanded Voluntary HIV Testing in India 

      Venkatesh, Kartik K.; Becker, Jessica E.; Kumarasamy, Nagalingeswaran; Nakamura, Yoriko M.; Mayer, Kenneth H.; Losina, Elena; Swaminathan, Soumya; Flanigan, Timothy P.; Walensky, Rochelle P.; Freedberg, Kenneth A. (Public Library of Science, 2013)
      Background: Despite expanding access to antiretroviral therapy (ART), most of the estimated 2.3 to 2.5 million HIV-infected individuals in India remain undiagnosed. The questions of whom to test for HIV and at what frequency ...
    • Cost-effectiveness of first-line antiretroviral therapy for HIV-infected African children less than 3 years of age 

      Ciaranello, Andrea L.; Doherty, Kathleen; Penazzato, Martina; Lindsey, Jane C.; Harrison, Linda; Kelly, Kathleen; Walensky, Rochelle P.; Essajee, Shaffiq; Losina, Elena; Muhe, Lulu; Wools-Kaloustian, Kara; Ayaya, Samuel; Weinstein, Milton C.; Palumbo, Paul; Freedberg, Kenneth A. (Lippincott Williams & Wilkins, 2015)
      Background: The International Maternal, Pediatric, and Adolescent Clinical Trials P1060 trial demonstrated superior outcomes for HIV-infected children less than 3 years old initiating antiretroviral therapy (ART) with ...
    • Cost-Effectiveness of Genotype Testing for Primary Resistance in Brazil 

      Luz, Paula M.; Morris, Bethany L.; Grinsztejn, Beatriz; Freedberg, Kenneth A.; Veloso, Valdilea G.; Walensky, Rochelle P.; Losina, Elena; Nakamura, Yoriko M.; Girouard, Michael P.; Sax, Paul E.; Struchiner, Claudio J.; Paltiel, A. David (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2014)
      Objective: HIV genotype-resistance testing can help identify more effective antiretroviral treatment (ART) regimens for patients, substantially increasing the likelihood of viral suppression and immune recovery. We sought ...
    • Cost-Effectiveness of HIV Testing Referral Strategies among Tuberculosis Patients in India 

      Uhler, Lauren M.; Kumarasamy, Nagalingeswaran; Saxena, Anjali; Muniyandi, Malaisamy; Stoler, Adam W.; Lu, Zhigang; Flanigan, Timothy P.; Bender, Melissa A.; Swaminathan, Soumya; Mayer, Kenneth H.; Losina, Elena; Walensky, Rochelle P.; Freedberg, Kenneth Alan; Swaminathan, Soumya (Public Library of Science, 2010)
      Background: Indian guidelines recommend routine referral for HIV testing of all tuberculosis (TB) patients in the nine states with the highest HIV prevalence, and selective referral for testing elsewhere. We assessed the ...
    • Cost-Effectiveness of Preventing Loss to Follow-up in HIV Treatment Programs: A Côte d'Ivoire Appraisal 

      Touré, Hapsatou; Uhler, Lauren M.; Anglaret, Xavier; Paltiel, A. David; Balestre, Eric; Messou, Eugène; Dabis, François; Losina, Elena; Walensky, Rochelle P.; Weinstein, Milton C.; Freedberg, Kenneth Alan (Public Library of Science, 2009)
      Background: Data from HIV treatment programs in resource-limited settings show extensive rates of loss to follow-up (LTFU) ranging from 5% to 40% within 6 mo of antiretroviral therapy (ART) initiation. Our objective was ...
    • The Cost-Effectiveness of Tuberculosis Preventive Therapy for HIV-Infected Individuals in Southern India: A Trial-Based Analysis 

      Pho, Mai T.; Swaminathan, Soumya; Kumarasamy, Nagalingeswaran; Losina, Elena; Ponnuraja, C.; Uhler, Lauren M.; Scott, Callie A.; Mayer, Kenneth Hugh; Freedberg, Kenneth Alan; Walensky, Rochelle P. (Public Library of Science, 2012)
      Background: Regimens for isoniazid-based preventive therapy (IPT) for tuberculosis (TB) in HIV-infected individuals have not been widely adopted given concerns regarding efficacy, adherence and drug resistance. Further, ...
    • Cost-Effectiveness of World Health Organization 2010 Guidelines for Prevention of Mother-to-Child HIV Transmission in Zimbabwe 

      Perez, Freddy; Engelsmann, Barbara; Mushavi, Angela; Rusibamayila, Asinath; Keatinge, Jo; Park, Ji-Eun; Maruva, Matthews; Wood, Robin; Dabis, Francois; Ciaranello, Andrea Lynne; Walensky, Rochelle P.; Cerda, Rodrigo; Freedberg, Kenneth Alan (Oxford University Press, 2012)
      Background. In 2010, the World Health Organization (WHO) released revised guidelines for prevention of mother-to-child human immunodeficiency virus (HIV) transmission (PMTCT). We projected clinical impacts, costs, and ...
    • Development, Calibration and Performance of an HIV Transmission Model Incorporating Natural History and Behavioral Patterns: Application in South Africa 

      McCormick, Alethea W.; Abuelezam, Nadia N.; Rhode, Erin R.; Hou, Taige; Walensky, Rochelle P.; Pei, Pamela P.; Becker, Jessica E.; DiLorenzo, Madeline A.; Losina, Elena; Freedberg, Kenneth A.; Lipsitch, Marc; Seage, George R. (Public Library of Science, 2014)
      Understanding HIV transmission dynamics is critical to estimating the potential population-wide impact of HIV prevention and treatment interventions. We developed an individual-based simulation model of the heterosexual ...
    • Drug-Resistant Tuberculosis among HIV-Infected Patients Starting Antiretroviral Therapy in Durban, South Africa 

      Hom, Jeffrey K.; Wang, Bingxia; Chetty, Senica; Giddy, Janet; Mazibuko, Matilda; Allen, Jenny; Walensky, Rochelle P.; Losina, Elena; Freedberg, Kenneth Alan; Bassett, Ingrid Valerie (Public Library of Science, 2012)
      Objective: To estimate the prevalence of drug-resistant tuberculosis (TB) and describe the resistance patterns in patients commencing antiretroviral therapy (ART) in an HIV clinic in Durban, South Africa. Design ...
    • Effectiveness of first-line antiretroviral therapy in the IPEC cohort, Rio de Janeiro, Brazil 

      Cardoso, Sandra W; Luz, Paula M; Velasque, Luciane; Torres, Thiago; Coelho, Lara; Freedberg, Kenneth A; Veloso, Valdilea G; Walensky, Rochelle P; Grinsztejn, Beatriz (BioMed Central, 2014)
      Background: While Brazil has had a long-standing policy of free access to antiretroviral therapy (ART) for all in need, the epidemiological impact of ART on human immunodeficiency virus (HIV) RNA suppression in this ...
    • Factors Associated with Self-Reported Repeat HIV Testing after a Negative Result in Durban, South Africa 

      Regan, Susan; Losina, Elena; Chetty, Senica; Giddy, Janet; Walensky, Rochelle P.; Ross, Douglas Sterling; Holst, Helga; Katz, Jeffrey Neil; Freedberg, Kenneth Alan; Bassett, Ingrid Valerie (Public Library of Science, 2013)
      Background: Routine screening for HIV infection leads to early detection and treatment. We examined patient characteristics associated with repeated screening in a high prevalence country. Methods: We analyzed data from a ...
    • HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy? 

      Sax, Paul E.; Sypek, Alexis; Berkowitz, Bethany K.; Morris, Bethany L.; Losina, Elena; Paltiel, A. David; Kelly, Kathleen A.; Seage, George R.; Walensky, Rochelle P.; Weinstein, Milton C.; Eron, Joseph; Freedberg, Kenneth A. (Public Library of Science, 2014)
      Background: We examined efficacy, toxicity, relapse, cost, and quality-of-life thresholds of hypothetical HIV cure interventions that would make them cost-effective compared to life-long antiretroviral therapy (ART). ...
    • The Impact of Reporting a Prior Penicillin Allergy on the Treatment of Methicillin-Sensitive Staphylococcus aureus Bacteremia 

      Blumenthal, Kimberly G.; Shenoy, Erica S.; Huang, Mingshu; Kuhlen, James L.; Ware, Winston A.; Parker, Robert A.; Walensky, Rochelle P. (Public Library of Science, 2016)
      Background: Methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia is a morbid infection with mortality benefit from receipt of parenteral β-lactam therapy. A substantial portion of MSSA bacteremia patients report ...
    • The Linkage Outcomes of a Large-scale, Rapid Transfer of HIV-infected Patients From Hospital-based to Community-based Clinics in South Africa 

      Cloete, Christie; Regan, Susan; Giddy, Janet; Govender, Tessa; Erlwanger, Alison; Gaynes, Melanie R.; Freedberg, Kenneth A.; Katz, Jeffrey N.; Walensky, Rochelle P.; Losina, Elena; Bassett, Ingrid V. (Oxford University Press, 2014)
      Background: President's Emergency Plan for AIDS Relief (PEPFAR) funding changes have resulted in human immunodeficiency virus (HIV) clinic closures. We evaluated linkage to care following a large-scale patient transfer ...
    • Linkage to HIV, TB and Non-Communicable Disease Care from a Mobile Testing Unit in Cape Town, South Africa 

      Govindasamy, Darshini; Kranzer, Katharina; van Schaik, Nienke; Noubary, Farzad; Wood, Robin; Walensky, Rochelle P.; Freedberg, Kenneth A.; Bassett, Ingrid V.; Bekker, Linda-Gail (Public Library of Science, 2013)
      Background: HIV counseling and testing may serve as an entry point for non-communicable disease screening. Objectives: To determine the yield of newly-diagnosed HIV, tuberculosis (TB) symptoms, diabetes and hypertension, ...
    • Missed Opportunities: Refusal to Confirm Reactive Rapid HIV Tests in the Emergency Department 

      Ganguli, Ishani; Collins, Jamie E.; Reichmann, William M.; Losina, Elena; Katz, Jeffrey Neil; Arbelaez, Christian; Donnell-Fink, Laurel A.; Walensky, Rochelle P. (Public Library of Science, 2013)
      Background: HIV infection remains a major US public health concern. While HIV-infected individuals now benefit from earlier diagnosis and improved treatment options, progress is tempered by large numbers of newly diagnosed ...
    • Mobile HIV Screening in Cape Town, South Africa: Clinical Impact, Cost and Cost-Effectiveness 

      Bassett, Ingrid V.; Govindasamy, Darshini; Erlwanger, Alison S.; Hyle, Emily P.; Kranzer, Katharina; van Schaik, Nienke; Noubary, Farzad; Paltiel, A. David; Wood, Robin; Walensky, Rochelle P.; Losina, Elena; Bekker, Linda-Gail; Freedberg, Kenneth A. (Public Library of Science, 2014)
      Background: Mobile HIV screening may facilitate early HIV diagnosis. Our objective was to examine the cost-effectiveness of adding a mobile screening unit to current medical facility-based HIV testing in Cape Town, South ...
    • Natural history of colonization with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE): a systematic review 

      Shenoy, Erica S; Paras, Molly L; Noubary, Farzad; Walensky, Rochelle P; Hooper, David C (BioMed Central, 2014)
      Background: No published systematic reviews have assessed the natural history of colonization with methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE). Time to clearance of ...