Browsing by Author "Gangl, Matthew"

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A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid utilization

Liu, Sihao; Brown, Jonathan D.; Stanya, Kristopher J.; Homan, Edwin; Leidl, Mathias; Inouye, Karen; Bhargava, Prerna; Gangl, Matthew R.; Dai, Lingling; Hatano, Ben; Hotamisligil, Gökhan S.; Saghatelian, Alan; Plutzky, Jorge; Lee, Chih-Hao (2014)

Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage or utilization. In mice, this program follows a circadian rhythm that peaks with nocturnal ...
Establishing an Ex Vivo Skin-Like Microenvironment Using Hydrogels to Study Macrophage-Tumor Interactions

Gangl, Matthew (2016-05-05)

Cancers are among the leading causes of morbidity and mortality worldwide. The disease manifests as mutations in native cells disrupt natural cellular proliferative or apoptotic mechanisms. Cancers form and mature in ...
Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways

Bhargava, Prerna; Li, Changlin; Stanya, Kristopher J; Jacobi, David; Dai, Lingling; Liu, Sihao; Gangl, Matthew; Harn, Donald A.; Lee, Chih-Hao (2012)

Parasitic worms express host-like glycans to attenuate the immune response of human hosts. The therapeutic potential of this immunomodulatory mechanism in controlling metabolic dysfunction associated with chronic inflammation ...