Browsing by Author "Rota, Marcello"

Now showing items 1-3 of 3

    • Essential Role of Diastolic Oscillatory Potentials in Adrenergic Control of Guinea Pig Sino-Atrial Node Discharge 

      Vassalle, Mario; Catanzaro, John N; Nett, Michael P; Rota, Marcello (BioMed Central, 2009)
      Background: The diastolic oscillatory after-potential Vos and pre-potential ThVos play an essential role in the pacemaker mechanism of sino-atrial node (SAN). The aim of this study was to investigate whether these oscillatory ...

    • Late Na+ current and protracted electrical recovery are critical determinants of the aging myopathy 

      Signore, Sergio; Sorrentino, Andrea; Borghetti, Giulia; Cannata, Antonio; Meo, Marianna; Zhou, Yu; Kannappan, Ramaswamy; Pasqualini, Francesco; O'Malley, Heather; Sundman, Mark; Tsigkas, Nikolaos; Zhang, Eric; Arranto, Christian; Mangiaracina, Chiara; Isobe, Kazuya; Sena, Brena F.; Kim, Junghyun; Goichberg, Polina; Nahrendorf, Matthias; Isom, Lori L.; Leri, Annarosa; Anversa, Piero; Rota, Marcello (Nature Pub. Group, 2015)
      The aging myopathy manifests itself with diastolic dysfunction and preserved ejection fraction. We raised the possibility that, in a mouse model of physiological aging, defects in electromechanical properties of cardiomyocytes ...

    • Reduction in Kv Current Enhances the Temporal Dispersion of the Action Potential in Diabetic Myocytes: Insights From a Novel Repolarization Algorithm 

      Meo, Marianna; Meste, Olivier; Signore, Sergio; Sorrentino, Andrea; Cannata, Antonio; Zhou, Yu; Matsuda, Alex; Luciani, Marco; Kannappan, Ramaswamy; Goichberg, Polina; Leri, Annarosa; Anversa, Piero; Rota, Marcello (John Wiley and Sons Inc., 2016)
      Background: Diabetes is associated with prolongation of the QT interval of the electrocardiogram and enhanced dispersion of ventricular repolarization, factors that, together with atherosclerosis and myocardial ischemia, ...