Browsing by Author "Dalli, Jesmond P"

Now showing items 1-7 of 7

    • Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages 

      Deng, Bin; Wang, Chin-Wei; Arnardottir, Hildur H.; Li, Yongsheng; Cheng, Chien-Yee Cindy; Dalli, Jesmond; Serhan, Charles N. (Public Library of Science, 2014)
      Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic ...

    • Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis 

      Dalli, Jesmond; Norling, Lucy V; Montero-Melendez, Trinidad; Canova, Donata Federici; Lashin, Hazem; Pavlov, Anton M; Sukhorukov, Gleb B; Hinds, Charles J; Perretti, Mauro (Blackwell, 2014)
      Incorporation of locally produced signaling molecules into cell-derived vesicles may serve as an endogenous mediator delivery system. We recently reported that levels alpha-2-macroglobulin (A2MG)-containing microparticles ...

    • Novel n-3 Immunoresolvents: Structures and Actions 

      Dalli, Jesmond; Colas, Romain A.; Serhan, Charles N. (Nature Publishing Group, 2013)
      Resolution of inflammation is now held to be an active process where autacoids promote homeostasis. Using functional-metabololipidomics and in vivo systems, herein we report that endogenous n-3 docosapentaenoic (DPA) acid ...

    • Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study 

      Frediani, Jennifer K.; Jones, Dean P.; Tukvadze, Nestan; Uppal, Karan; Sanikidze, Eka; Kipiani, Maia; Tran, ViLinh T.; Hebbar, Gautam; Walker, Douglas I.; Kempker, Russell R.; Kurani, Shaheen S.; Colas, Romain A.; Dalli, Jesmond; Tangpricha, Vin; Serhan, Charles N.; Blumberg, Henry M.; Ziegler, Thomas R. (Public Library of Science, 2014)
      We aimed to characterize metabolites during tuberculosis (TB) disease and identify new pathophysiologic pathways involved in infection as well as biomarkers of TB onset, progression and resolution. Such data may inform ...

    • Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA 

      Fredman, Gabrielle; Li, Yongsheng; Dalli, Jesmond P; Chiang, Nan; Serhan, Charles Nicholas (Nature Publishing Group, 2012)
      Mechanisms underlying delays in resolution programs of inflammation are of interest for many diseases. Here, we addressed delayed resolution of inflammation and identified specific microRNA (miR)-metabolipidomic signatures. ...

    • Total Synthesis of the Lipid Mediator PD1n-3 DPA: Configurational Assignments and Anti-inflammatory and Pro-resolving Actions 

      Aursnes, Marius; Tungen, Jørn E.; Vik, Anders; Colas, Romain; Cheng, Chien-Yee C.; Dalli, Jesmond; Serhan, Charles N.; Hansen, Trond V. (American Chemical Society and American Society of Pharmacognosy, 2014)
      The polyunsaturated lipid mediator PD1n-3 DPA (5) was recently isolated from self-resolving inflammatory exudates of 5 and human macrophages. Herein, the first total synthesis of PD1n-3 DPA (5) is reported in 10 steps and ...

    • Vagus nerve controls resolution and pro-resolving mediators of inflammation 

      Mirakaj, Valbona; Dalli, Jesmond; Granja, Tiago; Rosenberger, Peter; Serhan, Charles N. (The Rockefeller University Press, 2014)
      Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that the vagus nerve regulates local expression ...