Browsing by Author "Liao, Maofu"

Now showing items 1-7 of 7

    • Cryo-EM Structure of the Protein-Conducting ERAD Channel Hrd1 in Complex With Hrd3 

      Schoebel, Stefan; Mi, Wei; Stein, Alexander; Ovchinnikov, Sergey; Pavlovicz, Ryan; DiMaio, Frank; Baker, David; Chambers, Melissa G.; Su, Huayou; Li, Dongsheng; Rapoport, Tom; Liao, Maofu (Springer Science and Business Media LLC, 2017-07-06)
      Misfolded endoplasmic reticulum proteins are retro-translocated through the membrane into the cytosol, where they are poly-ubiquitinated, extracted from the membrane, and degraded by the proteasome—a pathway termed endoplasmic ...

    • Structural basis of coreceptor recognition by HIV-1 envelope spike 

      Shaik, Md Munan; Rits-Volloch, Sophia; Chen, Bing; Peng, Hanqin; Lu, Jianming; Liao, Maofu; Xu, Chen (Springer Science and Business Media LLC, 2018-12-12)
      HIV-1 envelope glycoprotein [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3] interacts with primary receptor CD4 and coreceptor (e.g. chemokine receptor CCR5 or CXCR4) to allow viral entry by catalyzing fusion of viral ...

    • Structural Basis of Lipopolysaccharide Extraction by the LptB2FGC Complex 

      Liao, Maofu; Orlando, Benjamin; Li, Yanyan (Springer Science and Business Media LLC, 2019-03)
      Lipopolysaccharide (LPS) in Gram-negative bacteria is essential for outer membrane formation and antibiotic resistance. The LPS transport proteins A-G (LptA-G) move LPS from the inner to outer membrane. The ATP-binding ...

    • Structure and Catalytic Mechanism of a Human Triacylglycerol-synthesis Enzyme 

      Sui, Xuewu; Wang, Kun; Gluchowski, Nina; Elliott, Shane; Liao, Maofu; Walther, Tobias; Farese, Robert (Springer Science and Business Media LLC, 2020-05-13)
      Triglycerides (triacylglycerols, TGs) store metabolic energy in organisms and have industrial uses for foods and fuels. Excessive accumulation of TGs in humans causes obesity and is associated with metabolic diseases1. TG ...

    • Structure and Mechanism of the Cation–chloride Cotransporter NKCC1 

      Wang, Amy; Liao, Maofu; Liang, Feng; Chew, Thomas; Orlando, Benjamin; Latorraca, Naomi; Zhang, Jinru; Hollingsworth, Scott; Chen, Dong-Hua; Dror, Ron (Springer Science and Business Media LLC, 2019-07-31)
      Cation-chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium, and/or sodium across the membrane. They play critical roles in regulating cell volume, controlling ion absorption and ...

    • Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex 

      Fan, Minrui; Zhang, Jinru; Tsai, Chen-Wei; Orlando, Benjamin J.; Rodriguez, Madison; Xu, Yan; Liao, Maofu; Tsai, Ming-Feng; Feng, Liang (Springer Science and Business Media LLC, 2020-05-20)

    • Sub-3 Å Cryo-EM Structure of RNA Enabled by Engineered Homomeric Self-Assembly 

      Liu, Di; Thelot, Francois; Liao, Maofu; Yin, Peng (Nature Portfolio, 2022-05-02)
      Though many functional RNAs fold into intricate and precise 3D architectures, it is difficult to acquire their high-resolution structures. Herein, we present a nanoarchitectural strategy for efficient structural determination ...