Now showing items 1-9 of 9

    • DIAPH3 Governs the Cellular Transition to the Amoeboid Tumour Phenotype 

      Hager, Martin H; Morley, Samantha; Bielenberg, Diane R; Gao, Sizhen; Morello, Matteo; Holcomb, Ilona N; Liu, Wennuan; Mouneimne, Ghassan; Demichelis, Francesca; Kim, Jayoung; Solomon, Keith R; Adam, Rosalyn M; Isaacs, William B; Higgs, Henry N; Vessella, Robert L; Di Vizio, Dolores; Freeman, Michael R (WILEY-VCH Verlag, 2012)
      Therapies for most malignancies are generally ineffective once metastasis occurs. While tumour cells migrate through tissues using diverse strategies, the signalling networks controlling such behaviours in human tumours ...
    • Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer 

      Ciardiello, Chiara; Cavallini, Lorenzo; Spinelli, Cristiana; Yang, Julie; Reis-Sobreiro, Mariana; de Candia, Paola; Minciacchi, Valentina Renè; Di Vizio, Dolores (MDPI, 2016)
      Extracellular Vesicles (EVs) have received considerable attention in recent years, both as mediators of intercellular communication pathways that lead to tumor progression, and as potential sources for discovery of novel ...
    • The impact of discrete modes of spinal cord injury on bladder muscle contractility 

      Seth, Abhishek; Chung, Yeun Goo; Kim, Daniel; Ramachandran, Aruna; Cristofaro, Vivian; Gomez III, Pablo; Tu, Duong D; Huang, Lin; Benowitz, Larry Ira; Di Vizio, Dolores; Sullivan, Maryrose P.; Adam, Rosalyn Mare (BioMed Central, 2013)
      Background: Prior studies have compared the effect of spinal cord injury elicited using distinct approaches on motor and visceral function. However, the impact of such discrete modes of injury specifically on bladder muscle ...
    • Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles 

      Minciacchi, Valentina R.; You, Sungyong; Spinelli, Cristiana; Morley, Samantha; Zandian, Mandana; Aspuria, Paul-Joseph; Cavallini, Lorenzo; Ciardiello, Chiara; Sobreiro, Mariana Reis; Morello, Matteo; Kharmate, Geetanjali; Jang, Su Chul; Kim, Dae-Kyum; Hosseini-Beheshti, Elham; Guns, Emma Tomlinson; Gleave, Martin; Gho, Yong Song; Mathivanan, Suresh; Yang, Wei; Freeman, Michael R.; Di Vizio, Dolores (Impact Journals LLC, 2015)
      Large oncosomes (LO) are atypically large (1-10μm diameter) cancer-derived extracellular vesicles (EVs), originating from the shedding of membrane blebs and associated with advanced disease. We report that 25% of the ...
    • Literature Lab: A Method of Automated Literature Interrogation to Infer Biology from Microarray Analysis 

      Febbo, Phillip G; Mulligan, Mike G; Slonina, David A; Stegmeir, Kimberly; Di Vizio, Dolores; Martinez, Paul R.; Loda, Massimo; Taylor, Stephen (BioMed Central, 2007)
      Background: The biomedical literature is a rich source of associative information but too vast for complete manual review. We have developed an automated method of literature interrogation called "Literature Lab" that ...
    • Rapid Preparation of Nuclei-Depleted Detergent-Resistant Membrane Fractions Suitable for Proteomics Analysis 

      Adam, Rosalyn Mare; Yang, Wei; Di Vizio, Dolores; Mukhopadhyay, Nishit K.; Steen, Hanno (BioMed Central, 2008)
      Background: Cholesterol-rich membrane microdomains known as lipid rafts have been implicated in diverse physiologic processes including lipid transport and signal transduction. Lipid rafts were originally defined as ...
    • Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes 

      Morley, Samantha; You, Sungyong; Pollan, Sara; Choi, Jiyoung; Zhou, Bo; Hager, Martin H.; Steadman, Kenneth; Spinelli, Cristiana; Rajendran, Kavitha; Gertych, Arkadiusz; Kim, Jayoung; Adam, Rosalyn M.; Yang, Wei; Krishnan, Ramaswamy; Knudsen, Beatrice S.; Di Vizio, Dolores; Freeman, Michael R. (Nature Publishing Group, 2015)
      Taxanes are widely employed chemotherapies for patients with metastatic prostate and breast cancer. Here, we show that loss of Diaphanous-related formin-3 (DIAPH3), frequently associated with metastatic breast and prostate ...
    • Skp2 Expression is Associated with High Risk and Elevated Ki67 Expression in Gastrointestinal Stromal Tumours 

      Di Vizio, Dolores; Demichelis, Francesca; Simonetti, Sara; Pettinato, Guido; Terracciano, Luigi; Tornillo, Luigi; Freeman, Michael R.; Insabato, Luigi (BioMed Central, 2008)
      Background: Gastrointestinal stromal tumors (GIST) exhibit an unpredictable clinical course and can rapidly progress to lethality. Predictions about the biological behavior of GIST are based on a number of canonical clinical ...
    • Trading in your spindles for blebs: the amoeboid tumor cell phenotype in prostate cancer 

      Morley, Samantha; Hager, Martin H; Pollan, Sara G; Knudsen, Beatrice; Di Vizio, Dolores; Freeman, Michael R (Medknow Publications & Media Pvt Ltd, 2014)
      Prostate cancer (PCa) remains a principal cause of mortality in developed countries. Because no clinical interventions overcome resistance to androgen ablation therapy, management of castration resistance and metastatic ...