Browsing by Author "Gorham, Joshua"
Now showing items 1-5 of 5
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Dissecting Spatio-Temporal Protein Networks Driving Human Heart Development and Related Disorders
Lage, Kasper; Møllgård, Kjeld; Greenway, Steven; Workman, Christopher T; Bendsen, Eske; Hansen, Niclas T; Rigina, Olga; Roque, Francisco S; Wiese, Cornelia; Christoffels, Vincent M; Tommerup, Niels; Brunak, Søren; Larsen, Lars A; Wakimoto, Hiroko; Gorham, Josh McClean; Roberts, Amy Elizabeth; Smoot, Leslie; Pu, William T.; Donahoe, Patricia; Seidman, Christine Edry; Seidman, Jonathan G. (Nature Publishing Group, 2010)Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems-level insight into the underlying processes is very limited. Using heart morphogenesis ... -
Loss of RNA expression and allele-specific expression associated with congenital heart disease
McKean, David M.; Homsy, Jason; Wakimoto, Hiroko; Patel, Neil; Gorham, Joshua; DePalma, Steven R.; Ware, James S.; Zaidi, Samir; Ma, Wenji; Patel, Nihir; Lifton, Richard P.; Chung, Wendy K.; Kim, Richard; Shen, Yufeng; Brueckner, Martina; Goldmuntz, Elizabeth; Sharp, Andrew J.; Seidman, Christine E.; Gelb, Bruce D.; Seidman, J. G. (Nature Publishing Group, 2016)Congenital heart disease (CHD), a prevalent birth defect occurring in 1% of newborns, likely results from aberrant expression of cardiac developmental genes. Mutations in a variety of cardiac transcription factors, ... -
Stable Gene Targeting in Human Cells Using Single-Strand Oligonucleotides with Modified Bases
Rios, Xavier; Briggs, Adrian; Christodoulou, Danos C.; Gorham, Josh McClean; Seidman, Jonathan G.; Church, George McDonald (Public Library of Science, 2012)Recent advances allow multiplexed genome engineering in E. coli, employing easily designed oligonucleotides to edit multiple loci simultaneously. A similar technology in human cells would greatly expedite functional genomics, ... -
Stable Gene Targeting in Human Cells Using Single-Strand Oligonucleotides with Modified Bases
Rios, Xavier; Briggs, Adrian W.; Christodoulou, Danos; Gorham, Joshua; Seidman, Jonathan; Church, George (Public Library of Science (PLoS), 2012-05-14)Recent advances allow multiplexed genome engineering in E. coli, employing easily designed oligonucleotides to edit multiple loci simultaneously. A similar technology in human cells would greatly expedite functional genomics, ... -
Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
Hinson, John Travis; Chopra, Anant; Nafissi, N.; Polacheck, William; Benson, Craig Carlyle; Swist, S.; Gorham, Joshua McClean; Yang, Luhan; Schafer, S.; Sheng, Calvin Chen; Haghighi, Alireza; Homsy, Jason George; Hubner, N.; Church, George McDonald; Cook, S. A.; Linke, Wolfgang; Chen, Christopher; Seidman, Jonathan G.; Seidman, Christine Edry (American Association for the Advancement of Science (AAAS), 2015)Human mutations that truncate the massive sarcomere protein titin [TTN-truncating variants (TTNtvs)] are the most common genetic cause for dilated cardiomyopathy (DCM), a major cause of heart failure and premature death. ...