Browsing by Author "Li, Zilin"

Now showing items 1-4 of 4

    • Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies 

      Li, Zilin; Li, Xihao; Liu, Yaowu; Shen, Jincheng; Chen, Han; Zhou, Hufeng; Morrison, Alanna C.; Boerwinkle, Eric; Lin, Xihong (Elsevier BV, 2019-05)
      Large-scale whole genome sequencing (WGS) studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests (RVATs) have limited scope to leverage variant ...

    • A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies 

      Li, Zilin; Xihao, Li; Zhou, Hufeng; Gaynor, Sheila M.; Arapoglou, Theodore; Quick, Corbin; Dey, Rounak; Xihong, Lin (Springer Science and Business Media LLC, 2022-10-27)
      Large-scale whole-genome sequencing (WGS) studies have enabled analysis of noncoding rare variant (RV) associations with complex human diseases and traits. Variant set analysis is a powerful approach to study RV association. ...

    • Genome sequencing analysis identifies Epstein–Barr virus subtypes associated with high risk of nasopharyngeal carcinoma 

      Xu, Miao; Yao, Youyuan; Chen, Hui; Zhang, Shanshan; Cao, Su-Mei; Zhang, Zhe; Luo, Bing; Liu, Zhiwei; Li, Zilin; Xiang, Tong; He, Guiping; Feng, Qi-Sheng; Chen, Li-Zhen; Guo, Xiang; Jia, Wei-Hua; Chen, Ming-Yuan; Zhang, Xiao; Xie, Shang-Hang; Peng, Roujun; Chang, Ellen T.; Pedergnana, Vincent; Feng, Lin; Bei, Jin-Xin; Xu, Rui-Hua; Zeng, Mu-Sheng; Ye, Weimin; Adami, Hans-Olov; Lin, Xihong; Zhai, Weiwei; Zeng, Yi-Xin; Liu, Jianjun (Springer Science and Business Media LLC, 2019-06-17)
      Epstein-Barr virus (EBV) infection is ubiquitous worldwide and associated with multiple cancers including nasopharyngeal carcinoma (NPC). The role of EBV viral genomic variation in NPC development and its striking endemicity ...

    • Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies 

      Li, Xihao; Quick, Corbin; Zhou, Hufeng; Gaynor, Sheila M.; Liu, Yaowu; Dey, Rounak; Li, Zilin; Lin, Xihong (Springer Science and Business Media LLC, 2022-12-23)
      Meta-analysis of whole-genome/exome sequencing (WGS/WES) studies provides an attractive solution to obtain large sample sizes from multiple studies for discovering rare variants associated with complex phenotypes. Existing ...