Browsing by Author "Dowling, David"

Now showing items 1-4 of 4

    • Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures* 

      Oh, Djin-Ye; Dowling, David J.; Ahmed, Saima; Choi, Hyungwon; Brightman, Spencer; Bergelson, Ilana; Berger, Sebastian T.; Sauld, John F.; Pettengill, Matthew; Kho, Alvin T.; Pollack, Henry J.; Steen, Hanno; Levy, Ofer (The American Society for Biochemistry and Molecular Biology, 2016)
      Adjuvants boost vaccine responses, enhancing protective immunity against infections that are most common among the very young. Many adjuvants activate innate immunity, some via Toll-Like Receptors (TLRs), whose activities ...

    • The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes 

      Ganapathi, Lakshmi; Van Haren, Simon; Dowling, David J.; Bergelson, Ilana; Shukla, Nikunj M.; Malladi, Subbalakshmi S.; Balakrishna, Rajalakshmi; Tanji, Hiromi; Ohto, Umeharu; Shimizu, Toshiyuki; David, Sunil A.; Levy, Ofer (Public Library of Science, 2015)
      Background: Newborns and young infants are at higher risk for infections than adults, and manifest suboptimal vaccine responses, motivating a search for novel immunomodulators and/or vaccine adjuvants effective in early ...

    • A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity 

      Dowling, David J.; Sanders, Holly; Cheng, Wing Ki; Joshi, Sweta; Brightman, Spencer; Bergelson, Ilana; Pietrasanta, Carlo; van Haren, Simon D.; van Amsterdam, Sandra; Fernandez, Jeffrey; van den Dobbelsteen, Germie P. J. M.; Levy, Ofer (Frontiers Media S.A., 2016)
      Background: Group B Neisseria meningitidis, an endotoxin-producing Gram-negative bacterium, causes the highest incidence of group B meningococcus (MenB) disease in the first year of life. The Bexsero vaccine is indicated ...

    • The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes 

      Dowling, David; Tan, Zhen; Prokopowicz, Zofia M.; Palmer, Christine D.; Matthews, Maura-Ann H.; Dietsch, Gregory N.; Hershberg, Robert M.; Levy, Ofer (Public Library of Science, 2013)
      Background: Newborns display distinct immune responses that contribute to susceptibility to infection and reduced vaccine responses. Toll-like receptor (TLR) agonists may serve as vaccine adjuvants, when given individually ...