Browsing by Author "Roccaro, Aldo M."

Now showing items 1-7 of 7

    • Advances in the Treatment of Monoclonal Gammopaties: The Emerging Role of Targeted Therapy in Plasma Cell Dyscrasias 

      Roccaro, Aldo M.; Ghobrial, Irene; Blotta, Simona; Treon, Steven P.; Malagola, Michele; Anderson, Kenneth Carl; Russo, Domenico (Dove Medical Press, 2008)
      The paradigm for the treatment of monoclonal gammopaties has dramatically changed: therapeutic options in multiple myeloma (MM) have evolved from the introduction of melphalan and prednisone in the 1960s, high-dose ...

    • Bone Marrow Microenvironment in Multiple Myeloma Progression 

      Manier, S.; Sacco, A.; Leleu, X.; Ghobrial, Irene; Roccaro, Aldo M. (Hindawi Publishing Corporation, 2012)
      Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, ...

    • Candidate genes of Waldenström’s macroglobulinemia: current evidence and research 

      Bianchi, Giada; Sacco, Antonio; Kumar, Shaji; Rossi, Giuseppe; Ghobrial, Irene; Roccaro, Aldo (Dove Medical Press, 2013)
      Waldenström’s macroglobulinemia (WM) is a relatively uncommon, indolent malignancy of immunoglobulin M-producing B cells. The World Health Organization classifies it as a lymphoplasmacytic lymphoma and patients typically ...

    • Front Line Treatment of Elderly Multiple Myeloma in the Era of Novel Agents 

      Venon, Marie-Dominique; Roccaro, Aldo M.; Gay, Julie; Moreau, Anne-Sophie; Dulery, Remy; Facon, Thierry; Ghobrial, Irene; Leleu, Xavier (Dove Medical Press, 2009)
      Melphalan combined with prednisone (MP) has long been the historical treatment of reference for a large proportion of elderly myeloma (MM) patients ineligible for autologous stem cell transplantation, and is still the ...

    • Global Epigenetic Regulation of MicroRNAs in Multiple Myeloma 

      Zhang, Wenjing; Wang, Yaoyu E.; Zhang, Yu; Leleu, Xavier; Reagan, Michaela; Zhang, Yong; Mishima, Yuji; Glavey, Siobhan; Manier, Salomon; Sacco, Antonio; Jiang, Bo; Roccaro, Aldo M.; Ghobrial, Irene M. (Public Library of Science, 2014)
      Epigenetic changes frequently occur during tumorigenesis and DNA hypermethylation may account for the inactivation of tumor suppressor genes in cancer cells. Studies in Multiple Myeloma (MM) have shown variable DNA methylation ...

    • Novel Tumor Suppressor Function of Glucocorticoid-Induced TNF Receptor GITR in Multiple Myeloma 

      Liu, Yang; Quang, Phong; Braggio, Esteban; Ngo, Hai; Badalian-Very, Gayane; Flores, Ludmila; Zhang, Yong; Sacco, Antonio; Maiso, Patricia; Azab, Abdel Kareem; Azab, Feda; Carrasco, Ruben; Rollins, Barrett J.; Roccaro, Aldo M.; Ghobrial, Irene M. (Public Library of Science, 2013)
      Glucocorticoid-induced TNF receptor (GITR) plays a crucial role in modulating immune response and inflammation, however the role of GITR in human cancers is poorly understood. In this study, we demonstrated that GITR is ...

    • Role of Dual PI3/Akt and mTOR Inhibition in Waldenstrom's Macroglobulinemia 

      Sacco, Antonio; Roccaro, Aldo M.; Ghobrial, Irene M. (Impact Journals LLC, 2010)
      Tumorigenesis occurs due to synergistic interactions from a complex of signal transduction processes, including multiple onco-proteins and tumor suppressors such as Ras, Myc, PI3K/Akt/mTOR, Her-2/Neu, p53 and PTEN. ...