Browsing by Author "Behar, Samuel M."
Now showing items 1-5 of 5
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Antimicrobial Roles for iNKT Cells and GM-CSF in Mycobacterium Tuberculosis Infection
Rothchild, Alissa Chen (2014-06-06)Despite effective antibiotics, Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, still infects nearly one-third of the world's population. While key immune factors including CD4+ T cells and IFNg ... -
Efferocytosis is an Innate Antibacterial Mechanism of Mycobacterium tuberculosis Control
Martin, Constance Jean (2012-12-13)One third of the world’s population is infected with Mycobacterium tuberculosis, causing two million deaths annually. The bacteria avoid immune clearance by persisting within macrophages by subverting normal phagosome ... -
EspA Acts as a Critical Mediator of ESX1-Dependent Virulence in Mycobacterium tuberculosis by Affecting Bacterial Cell Wall Integrity
Garces, Alejandra; Woodworth, Joshua S.; Krastins, Bryan; Atmakuri, Krishnamohan; Chase, Michael Richard; Rothchild, Alissa C.; Ramsdell, Talia Lynn; Lopez, Mary Frances; Behar, Samuel M; Sarracino, David A.; Fortune, Sarah Merritt (Public Library of Science, 2010)Mycobacterium tuberculosis (Mtb) requires the ESX1 specialized protein secretion system for virulence, for triggering cytosolic immune surveillance pathways, and for priming an optimal CD8+ T cell response. This suggests ... -
Lipid Mediators in Innate Immunity Against Tuberculosis: Opposing Roles of PGE2 and LXA4 in the Induction of Macrophage Death
Chen, Minjian; Divangahi, Maziar; Gan, Huixian; Shin, Daniel S.J.; Hong, Song; Lee, David Marvin; Serhan, Charles Nicholas; Behar, Samuel M; Remold, Heinz G (Rockefeller University Press, 2008)Virulent Mycobacterium tuberculosis (Mtb) induces a maladaptive cytolytic death modality, necrosis, which is advantageous for the pathogen. We report that necrosis of macrophages infected with the virulent Mtb strains H37Rv ... -
Regulation of Neutrophils by Interferon-\(\gamma\) Limits Lung Inflammation During Tuberculosis Infection
Nandi, Bisweswar; Behar, Samuel M (The Rockefeller University Press, 2011)Resistance to Mycobacterium tuberculosis requires the host to restrict bacterial replication while preventing an over-exuberant inflammatory response. Interferon (IFN) \(\gamma\) is crucial for activating macrophages and ...