Now showing items 1-5 of 5

    • Chamber identity programs drive early functional partitioning of the heart 

      Mosimann, Christian; Panáková, Daniela; Werdich, Andreas A.; Musso, Gabriel; Burger, Alexa; Lawson, Katy L.; Carr, Logan A.; Nevis, Kathleen R.; Sabeh, M. Khaled; Zhou, Yi; Davidson, Alan J.; DiBiase, Anthony; Burns, Caroline E.; Burns, C. Geoffrey; MacRae, Calum A.; Zon, Leonard I. (Nature Pub. Group, 2015)
      The vertebrate heart muscle (myocardium) develops from the first heart field (FHF) and expands by adding second heart field (SHF) cells. While both lineages exist already in teleosts, the primordial contributions of FHF ...
    • Characterization of immune-matched hematopoietic transplantation in zebrafish 

      de Jong, J. L. O.; Burns, Caroline Erter; Chen, A. T.; Pugach, E.; Mayhall, E. A.; Smith, A. C. H.; Feldman, Henry Arthur; Zhou, Yi; Zon, Leonard Ira (American Society of Hematology, 2011)
      Evaluating hematopoietic stem cell (HSC) function in vivo requires a long-term transplantation assay. Although zebrafish are a powerful model for discovering the genetics of hematopoiesis, hematopoietic transplantation ...
    • Heart field origin of great vessel precursors relies on nkx2.5-mediated vasculogenesis 

      Paffett-Lugassy, Noëlle; Singh, Reena; Nevis, Kathleen R.; Guner-Ataman, Burcu; O'Loughlin, Evan; Jahangiri, Leila; Harvey, Richard P.; Burns, C. Geoffrey; Burns, Caroline E. (2013)
      The pharyngeal arch arteries (PAAs) are transient embryonic blood vessels that make indispensable contributions to the carotid arteries and great vessels of the heart, including the aorta and pulmonary artery1, 2. During ...
    • Hematopoietic Defects in rps29 Mutant Zebrafish Depend Upon p53 Activation 

      Taylor, Alison Marie; Humphries, Jessica M.; White, Richard; Murphey, Ryan D.; Burns, Caroline Erter; Zon, Leonard Ira (Elsevier BV, 2012)
      Disruption of ribosomal proteins is associated with hematopoietic phenotypes in cell culture and animal models. Mutations in ribosomal proteins are seen in patients with Diamond Black- fan anemia, a rare congenital disease ...
    • Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration 

      Zhao, Long; Borikova, Asya; Ben-Yair, Raz; Guner-Ataman, Burcu; MacRae, Calum Archibald; Lee, Richard Theodore; Burns, Charles Geoffrey; Burns, Caroline Erter (Proceedings of the National Academy of Sciences, 2014)
      The human heart’s failure to replace ischemia-damaged myocardium with regenerated muscle contributes significantly to the worldwide morbidity and mortality associated with coronary artery disease. Remarkably, certain ...