Now showing items 1-5 of 5

    • Atrial natriuretic peptide is negatively regulated by microRNA-425 

      Arora, Pankaj; Wu, Connie; Khan, Abigail May; Bloch, Donald Bendit; Davis-Dusenbery, Brandi Nicole; Ghorbani, Anahita; Spagnolli, Ester; Martinez, Andrew; Ryan, Allicia; Tainsh, Laurel T.; Kim, Samuel M; Rong, Jian; Huan, Tianxiao; Freedman, Jane E.; Levy, Daniel; Miller, Karen Klahr; Hata, Akiko; Del Monte, Federica; Vandenwijngaert, Sara; Swinnen, Melissa; Janssens, Stefan; Holmes, Tara M.; Buys, Emmanuel; Bloch, Kenneth Daniel; Newton-Cheh, Christopher Holmes; Wang, Thomas (American Society for Clinical Investigation, 2013)
      Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the variant rs5068 (A/G) in the 3′ untranslated region of NPPA, ...
    • Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation 

      O'Rourke, Caitlin; Shelton, Georgia; Hutcheson, Joshua; Burke, Megan F.; Martyn, Trejeeve; Thayer, Timothy E.; Shakartzi, Hannah R.; Buswell, Mary D.; Tainsh, Robert; Yu, Binglan; Bagchi, Aranya; Rhee, David Kwan; Wu, Connie; Derwall, Matthias; Buys, Emmanuel; Yu, Paul B.; Bloch, Kenneth; Aikawa, Elena; Bloch, Donald Bendit; Malhotra, Rajeev (MyJove Corporation, 2016)
      Cardiovascular disease is the leading cause of morbidity and mortality in the world. Atherosclerotic plaques, consisting of lipid-laden macrophages and calcification, develop in the coronary arteries, aortic valve, aorta, ...
    • LMKB/MARF1 Localizes to mRNA Processing Bodies, Interacts with Ge-1, and Regulates IFI44L Gene Expression 

      Bloch, Donald B.; Li, Pingcheng; Bloch, Emily G.; Berenson, Daniel F.; Galdos, Rita L.; Arora, Pankaj; Malhotra, Rajeev; Wu, Connie; Yang, Weihong (Public Library of Science, 2014)
      The mRNA processing body (P-body) is a cellular structure that regulates the stability of cytoplasmic mRNA. MARF1 is a murine oocyte RNA-binding protein that is associated with maintenance of mRNA homeostasis and genomic ...
    • Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production 

      Wu, Connie; Arora, Pankaj; Agha, Obiajulu; Hurst, Liam A.; Allen, Kaitlin; Nathan, Daniel I.; Hu, Dongjian; Jiramongkolchai, Pawina; Smith, J. Gustav; Melander, Olle; Trenson, Sander; Janssens, Stefan P.; Domian, Ibrahim J.; Wang, Thomas J.; Bloch, Kenneth; Buys, Emmanuel; Bloch, Donald Bendit; Newton-Cheh, Christopher Holmes (American Society for Microbiology, 2016)
      Atrial natriuretic peptide (ANP) has a central role in regulating blood pressure in humans. Recently, microRNA 425 (miR-425) was found to regulate ANP production by binding to the mRNA of NPPA, the gene encoding ANP. mRNAs ...
    • Weight Loss, Saline Loading, and the Natriuretic Peptide System 

      Arora, P.; Reingold, J.; Baggish, Aaron L.; Guanaga, Derek Philip; Wu, Connie; Ghorbani, Anahita; Song, Y.; Chen-Tournaux, A.; Khan, A. M.; Tainsh, L. T.; Buys, Emmanuel; Williams, Jonathan Sylvan; Heublein, D. M.; Burnett, J. C.; Semigran, Marc J.; Bloch, K. D.; Scherrer-Crosbie, Marielle; Newton-Cheh, Christopher Holmes; Kaplan, Lee Michael; Wang, T. J. (Ovid Technologies (Wolters Kluwer Health), 2015)
      Background-—In epidemiologic studies, obesity has been associated with reduced natriuretic peptide (NP) concentrations. Reduced NP production could impair the ability of obese individuals to respond to salt loads, increasing ...