Browsing by Author "Zapol, Warren"

Now showing items 1-4 of 4

    • An Engineered Enzyme That Targets Circulating Lactate to Alleviate Intracellular NADH:NAD+ Imbalance 

      Patgiri, Anupam; Skinner, Owen; Miyazaki, Yusuke; Schleifer, Grigorij; Marutani, Eizo; Shah, Hardik; Sharma, Rohit; Goodman, Russell; To, Tsz-Leung; Bao, Xiaoyan; Ichinose, Fumito; Zapol, Warren; Mootha, Vamsi (Springer Science and Business Media LLC, 2020-01-13)
      An elevated intracellular NADH/NAD+ ratio, or “reductive stress,” has been associated with multiple diseases, including disorders of the mitochondrial electron transport chain (ETC). As the intracellular NADH/NAD+ ratio ...

    • Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling 

      Nakagawa, Akito; Lui, Francine E.; Wassaf, Dina; Yefidoff-Freedman, Revital; Casalena, Dominick; Palmer, Michelle A.; Meadows, Jacqueline; Mozzarelli, Andrea; Ronda, Luca; Abdulmalik, Osheiza; Bloch, Kenneth D.; Safo, Martin K.; Zapol, Warren M. (American Chemical Society, 2014)
      Small molecules that increase the oxygen affinity of human hemoglobin may reduce sickling of red blood cells in patients with sickle cell disease. We screened 38 700 compounds using small molecule microarrays and identified ...

    • Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene 

      Steinbicker, Andrea U.; Liu, Heling; Jiramongkolchai, Kim; Malhotra, Rajeev; Choe, Elizabeth Y.; Busch, Cornelius J.; Graveline, Amanda R; Kao, Sonya M.; Nagasaka, Yasuko; Ichinose, Fumito; Buys, Emmanuel; Brouckaert, Peter; Zapol, Warren Myron; Bloch, Kenneth Daniel (Elsevier BV, 2011)
      Nitric oxide (NO) regulates vascular smooth muscle cell (VSMC) structure and function, in part by activating soluble guanylate cyclase (sGC) to synthesize cGMP. The objective of this study was to further characterize the ...

    • Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. 

      Steudel, W; Scherrer-Crosbie, Marielle; Bloch, K D; Weimann, J; Huang, P L; Jones, R C; Picard, Michael Howard; Zapol, Warren Myron (American Society for Clinical Investigation, 1998)
      Chronic hypoxia induces pulmonary hypertension and right ventricular (RV) hypertrophy. Nitric oxide (NO) has been proposed to modulate the pulmonary vascular response to hypoxia. We investigated the effects of congenital ...