Now showing items 1-4 of 4

    • Detection of Single-Molecule Optical Absorption at Room Temperature and Mechanistic Study of Transcriptional Bursting 

      Chong, Shasha (2014-06-06)
      Advances in optical imaging techniques have allowed quantitative studies of many biological systems. This dissertation elaborates on our efforts in both developing novel imaging modalities based on detection of optical ...
    • Imaging Chromophores With Undetectable Fluorescence by Stimulated Emission Microscopy 

      Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary; Xie, Xiaoliang Sunney (Nature Publishing Group, 2009)
      Fluorescence, that is, spontaneous emission, is generally more sensitive than absorption measurement, and is widely used in optical imaging. However, many chromophores, such as haemoglobin and cytochromes, absorb but have ...
    • Mechanism of Transcriptional Bursting in Bacteria 

      Chong, Shasha; Xie, Xiaoliang Sunney (2015-08-07)
    • Probing Allostery through DNA 

      Kim, Sangjin; Broströmer, Erik; Jin, Jianshi; Chong, Shasha; Ge, Hao; Wang, Siyuan; Gu, Chan; Yang, Lijiang; Gao, Yi Qin; Su, Xiao-dong; Sun, Yujie; Xie, Xiaoliang Sunney; Xing, Dong (American Association for the Advancement of Science, 2013)
      Allostery is well documented for proteins but less recognized for DNA-protein interactions. Here, we report that specific binding of a protein on DNA is substantially stabilized or destabilized by another protein bound ...