Now showing items 1-5 of 5

    • Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells 

      Ng, Samuel Yao-Ming; Yoshida, Toshimi; Zhang, Jiangwen; Georgopoulos, Katia (Elsevier BV, 2009)
      The mechanisms regulating lineage potential during early hematopoiesis were investigated. First, a cascade of lineage-affiliated gene expression signatures, primed in hematopoietic stem cells (HSCs) and differentially ...
    • Inhibitors of Pathogen Intercellular Signals as Selective Anti-Infective Compounds 

      Lesic, Biliana; Lépine, François; Déziel, Eric; Zhang, Qunhao; Padfield, Katie; Castonguay, Marie-Hélène; Milot, Sylvain; Stachel, Scott; Zhang, Jiangwen; Tzika, A. Aria; Tompkins, Ronald Gary; Rahme, Laurence G. (Public Library of Science, 2007)
      Long-term antibiotic use generates pan-resistant super pathogens. Anti-infective compounds that selectively disrupt virulence pathways without affecting cell viability may be used to efficiently combat infections caused ...
    • Innate Immunity and the Evolution of Resistance to an Emerging Infectious Disease in a Wild Bird 

      Bonneaud, Camille; Balenger, Susan L.; Zhang, Jiangwen; Edwards, Scott V.; Hill, Geoffrey E. (Wiley Blackwell (Blackwell Publishing), 2012)
      Innate immunity is expected to play a primary role in conferring resistance to novel infectious diseases, but few studies have attempted to examine its role in the evolution of resistance to emerging pathogens in wild ...
    • The role of the chromatin remodeler Mi-2β in hematopoietic stem cell self-renewal and multilineage differentiation 

      Yoshida, Toshimi; Hazan, Idit; Zhang, Jiangwen; Ng, Samuel Yao-Ming; Naito, Taku; Snippert, Hugo; Heller, Elizabeth; Qi, Xiaoqing; Lawton, L. N.; Williams, Christine; Georgopoulos, Katia (Cold Spring Harbor Laboratory Press, 2008)
      The ability of somatic stem cells to self-renew and differentiate into downstream lineages is dependent on specialized chromatin environments that keep stem cell-specific genes active and key differentiation factors repressed ...
    • Stochastic Expression of the Interferon-β Gene 

      Zhao, Mingwei; Zhang, Jiangwen; Phatnani, Hemali; Scheu, Stefanie; Maniatis, Thomas P. (Public Library of Science, 2012)
      Virus infection of mammalian cells induces the production of high levels of type I interferons (IFNα and β), cytokines that orchestrate antiviral innate and adaptive immunity. Previous studies have shown that only a fraction ...