Browsing by Author "Thornton, James Edward"
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Roles for Terminal Uridyl Transferases in the Post-Transcriptional Regulation of Developmental miRNAs
Thornton, James Edward (2013-10-18)MicroRNAs (miRNAs) are a diverse and evolutionarily conserved class of non-coding RNAs that play a multitude of roles in many branches of eukaryotic biology. The regulation of miRNAs is dynamically controlled both spatially ... -
Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation
Chang, Hao-Ming; Martinez, Natalia J; Thornton, James Edward; Gregory, Richard Ian (Nature Publishing Group, 2012)Pluripotent embryonic stem cells (ESCs) have a shortened cell cycle that enables their rapid proliferation. The ESC-specific miR-290 and miR-302 microRNA families promote proliferation whereas let-7 microRNAs inhibit ...