Now showing items 1-20 of 43

    • 3D structure of individual nanocrystals in solution by electron microscopy 

      Park, Jungwon; Elmlund, Hans; Ericus, Peter; Yuk, Jong Min; Limmer, David T.; Chen, Qian; Kim, Kwanpyo; Han, Sang Hoon; Weitz, David A.; Zettl, A.; Alivisatos, A. Paul (American Association for the Advancement of Science (AAAS), 2015)
      Understanding structural details of colloidal nanoparticles is required to bridge our knowledge about their synthesis, growth mechanisms, and physical properties. We introduce a method for determining 3D structures of ...
    • Airborne Disease Transmission via Bioaerosols: Formation Mechanisms and the Influence of Viscoelasticity 

      Thomas, Matthew K (2013-03-18)
      Airborne disease transmission is a prominent problem facing an increasingly mobilized world. It involves small droplets (bioaerosols) containing pathogens which form in the lungs and are expelled to the environment, where ...
    • Clogging Mechanisms in Converging Microchannels 

      Massenburg, Sorell S. (2016-01-29)
      Many technological and biomedical applications ranging from water filtration and oil extraction to arteriosclerosis and vein thrombosis rely upon the transport of solids in liquids. Particulate matter suspended in liquid ...
    • Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition 

      Burger, Jan A.; Landau, Dan A.; Taylor-Weiner, Amaro; Bozic, Ivana; Zhang, Huidan; Sarosiek, Kristopher; Wang, Lili; Stewart, Chip; Fan, Jean; Hoellenriegel, Julia; Sivina, Mariela; Dubuc, Adrian M.; Fraser, Cameron; Han, Yulong; Li, Shuqiang; Livak, Kenneth J.; Zou, Lihua; Wan, Youzhong; Konoplev, Sergej; Sougnez, Carrie; Brown, Jennifer R.; Abruzzo, Lynne V.; Carter, Scott L.; Keating, Michael J.; Davids, Matthew S.; Wierda, William G.; Cibulskis, Kristian; Zenz, Thorsten; Werner, Lillian; Cin, Paola Dal; Kharchencko, Peter; Neuberg, Donna; Kantarjian, Hagop; Lander, Eric; Gabriel, Stacey; O'Brien, Susan; Letai, Anthony; Weitz, David A.; Nowak, Martin A.; Getz, Gad; Wu, Catherine J. (Nature Publishing Group, 2016)
      Resistance to the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely to mutations in BTK and related pathway molecules. Using whole-exome and deep-targeted sequencing, we dissect evolution of ...
    • Crystal-Liquid Transitions Studied With Colloids in an Electric Bottle 

      Hwang, Hyerim (2016-05-18)
      In this thesis, we have presented the experimental investigations on the crystal-liquid transitions in a colloidal system. Colloids behave as big atoms, thus they are good model systems to study the dynamics of condensed ...
    • Cytoplasmic Diffusion: Molecular Motors Mix It Up 

      Brangwynne, Clifford P.; Koenderink, Gijsje H.; MacKintosh, Frederick C.; Weitz, David A. (The Rockefeller University Press, 2008)
      Random motion within the cytoplasm gives rise to molecular diffusion; this motion is essential to many biological processes. However, in addition to thermal Brownian motion, the cytoplasm also undergoes constant agitation ...
    • Delayed Buckling and Guided Folding of Inhomogeneous Capsules 

      Datta, Sujit; Kim, Shin-Hyun; Paulose, Jayson; Abbaspourrad, Alireza; Nelson, David R.; Weitz, David A. (American Physical Society, 2012)
      Colloidal capsules can sustain an external osmotic pressure; however, for a sufficiently large pressure, they will ultimately buckle. This process can be strongly influenced by structural inhomogeneities in the capsule ...
    • Drop-Based Microfluidics for Biological Applications 

      Zhang, Yizhe (2015-05-17)
      Drop-based microfluidic technology has been attracting great attention since the prevalence of soft-lithography techniques in poly-dimethylsiloxane (PDMS) microfluidic device fabrication a decade ago. The miniaturized ...
    • Droplet Microfluidics: Tools for Screening and Sorting Applications 

      Aubrecht, Donald Michael (2013-10-15)
      Microfluidic droplets are a powerful tool for screening large populations of cells, molecules, and biochemical reactions. Droplet systems are able to encapsulate, incubate, screen, and sort millions of samples, providing ...
    • Dynamics of Charged Colloids in Nonpolar Solvents 

      Lin, Tina (2013-09-04)
      Charging is typically not expected in nonpolar environments due to a high electrostatic barrier to charge dissociation. Nevertheless, charge effects are observed in such environments upon the addition of surfactants, which ...
    • Elasticity of Compressed Emulsions 

      Guerra, Rodrigo Emigdio (2014-06-06)
      The interfaces of bubbles and droplets imbue foams and emulsions with extraordinary mechanical and chemical properties. The remarkably large interfacial area of these structures controls their thermodynamics and makes ...
    • Experimental Observation of the Crystallization of Hard-Sphere Colloidal Particles by Sedimentation onto Flat and Patterned Surfaces 

      Ramsteiner, I.B.; Jensen, Katharine Estelle; Weitz, David A.; Spaepen, Frans A. (American Physical Society, 2009)
      We present a confocal microscopy study of 1.55micrometers monodisperse silica hard spheres as they sediment and crystallize at the bottom wall of a container. If the particles sediment onto a featureless flat wall, the two ...
    • Getting Out Of A Tight Spot: Physics Of Flow Through Porous Materials 

      Datta, Sujit Sankar (2013-10-15)
      We study the physics of flow through porous materials in two different ways: by directly visualizing flow through a model three-dimensional (3D) porous medium, and by investigating the deformability of fluid-filled ...
    • Graphene-templated directional growth of an inorganic nanowire 

      Lee, Won Chul; Kim, Kwanpyo; Park, Jungwon; Koo, Jahyun; Jeong, Hu Young; Lee, Hoonkyung; Weitz, David A.; Zettl, Alex; Takeuchi, Shoji (Nature Publishing Group, 2015)
      Assembling inorganic nanomaterials on graphene1-3 holds great promise 1 in nanodevices and nanocomposite materials. Adding alignments in the assembly is expected to advance its functionalities, as previously demonstrated ...
    • High-Throughput Single-Cell Labeling (Hi-SCL) for RNA-Seq Using Drop-Based Microfluidics 

      Rotem, Assaf; Ram, Oren; Shoresh, Noam; Sperling, Ralph A.; Schnall-Levin, Michael; Zhang, Huidan; Basu, Anindita; Bernstein, Bradley E.; Weitz, David A. (Public Library of Science, 2015)
      The importance of single-cell level data is increasingly appreciated, and significant advances in this direction have been made in recent years. Common to these technologies is the need to physically segregate individual ...
    • Isolation and Analysis of Rare Norovirus Recombinants from Coinfected Mice Using Drop-Based Microfluidics 

      Zhang, Huidan; Cockrell, Shelley K.; Kolawole, Abimbola O.; Rotem, Assaf; Serohijos, Adrian; Chang, Connie B.; Tao, Ye; Mehoke, Thomas S.; Han, Yulong; Lin, Jeffrey S.; Giacobbi, Nicholas S.; Feldman, Andrew B.; Shakhnovich, Eugene Isaacovitch; Weitz, David A.; Wobus, Christiane E.; Pipas, James M. (American Society for Microbiology, 2015)
      Human noroviruses (HuNoVs) are positive-sense RNA viruses that can cause severe, highly infectious gastroenteritis. HuNoV outbreaks are frequently associated with recombination between circulating strains. Strain genotyping ...
    • Label-free single-cell protein quantification using a drop-based mix-and-read system 

      Abbaspourrad, Alireza; Zhang, Huidan; Tao, Ye; Cui, Naiwen; Asahara, Haruichi; Zhou, Ying; Yue, Dongxian; Koehler, Stephan A.; Ung, Lloyd W.; Heyman, John; Ren, Yukun; Ziblat, Roy; Chong, Shaorong; Weitz, David A. (Nature Publishing Group, 2015)
      Quantitative protein analysis of single cells is rarely achieved due to technical difficulties of detecting minute amounts of proteins present in one cell. We develop a mix-and-read assay for drop-based label-free protein ...
    • Local shear transformations in deformed and quiescent hard-sphere colloidal glasses 

      Jensen, Karen; Weitz, David A.; Spaepen, Frans A. (American Physical Society (APS), 2014)
      We performed a series of deformation experiments on a monodisperse, hard-sphere colloidal glass while simultaneously following the 3D trajectories of roughly 50,000 individual particles with a confocal microscope. In each ...
    • Magnetic Spheres in Viscous Flows and at Interfaces: Sorting, Coating, and Interfacial Deformation 

      Tsai, Scott (2013-02-11)
      Magnetic microparticles are often used in laboratory settings for the separation of biological material. These microparticles can also be useful in microfluidic settings because of their small size and the possibility of ...
    • Mechanical Failure in Colloidal Gels 

      Kodger, Thomas Edward (2015-01-16)
      When colloidal particles in a dispersion are made attractive, they aggregate into fractal clusters which grow to form a space-spanning network, or gel, even at low volume fractions. These gels are crucial to the rheological ...