Browsing by Author "Kubler, Kirsten"

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    • RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues 

      Yizhak, Keren; Aguet, Francois; Kim, Jaegil; Hess, Julian; Kubler, Kirsten; Grimsby, Jonna; Frazer, Ruslana; Zhang, Hailei; Haradhvala, Nicholas; Rosebrock, Daniel; Livitz, Dimitri; Li, Xiao; Arich-Landkof, Eila; Shoresh, Noam; Stewart, Chip; Segre, Ayelet; Branton, Philip A; Polak, Paz; Ardlie, Kristin; Getz, Gad (American Association for the Advancement of Science (AAAS), 2019-06-06)
      How somatic mutations accumulate in normal cells is poorly understood. A comprehensive analysis of RNA-sequencing data from ~6,700 samples across 29 normal tissues reveals multiple somatic variants, demonstrating that ...