Now showing items 1-4 of 4

    • Energetics of Protein–DNA Interactions 

      Donald, Jason E.; Chen, William Wei-Lun; Shakhnovich, Eugene Isaacovitch (Oxford University Press, 2007)
      Protein–DNA interactions are vital for many processes in living cells, especially transcriptional regulation and DNA modification. To further our understanding of these important processes on the microscopic level, it is ...
    • Exploring the Contextual Sensitivity of Factors that Determine Cell-to-Cell Variability in Receptor-Mediated Apoptosis 

      Gaudet, Suzanne; Spencer, Sabrina L.; Chen, William Wei-Lun; Sorger, Peter Karl (Public Library of Science, 2012)
      Stochastic fluctuations in gene expression give rise to cell-to-cell variability in protein levels which can potentially cause variability in cellular phenotype. For TRAIL (TNF-related apoptosis-inducing ligand) variability ...
    • Input–Output Behavior of ErbB Signaling Pathways as Revealed by a Mass Action Model Trained against Dynamic Data 

      Chen, William Wei-Lun; Schoeberl, Birgit; Jasper, Paul J; Niepel, Mario; Nielsen, Ulrik B; Lauffenburger, Douglas A; Sorger, Peter Karl (Nature Publishing Group, 2009)
      The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis. Nonetheless, it remains poorly understood ...
    • Properties of cell death models calibrated and compared using Bayesian approaches 

      Eydgahi, Hoda; Chen, William Wei-Lun; Muhlich, Jeremy; Vitkup, Dennis; Tsitsiklis, John N; Sorger, Peter Karl (Nature Publishing Group, 2013)
      Using models to simulate and analyze biological networks requires principled approaches to parameter estimation and model discrimination. We use Bayesian and Monte Carlo methods to recover the full probability distributions ...