Browsing by Author "AlQuraishi, Mohammed"

Now showing items 1-3 of 3

An affinity-structure database of helix-turn-helix: DNA complexes with a universal coordinate system

AlQuraishi, Mohammed; Tang, Shengdong; Xia, Xide (BioMed Central, 2015)

Background: Molecular interactions between proteins and DNA molecules underlie many cellular processes, including transcriptional regulation, chromosome replication, and nucleosome positioning. Computational analyses of ...
Biophysical Prediction of Protein-Peptide Interactions and Signaling Networks Using Machine Learning

Cunningham, Joseph; Koytiger, Grigoriy; Sorger, Peter; AlQuraishi, Mohammed (Springer Science and Business Media LLC, 2020-01-06)

In mammalian cells, much of signal transduction is mediated by weak protein-protein interactions between globular peptide-binding domains (PBDs) and unstructured peptidic motifs in partner proteins. The number and diversity ...
A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks

AlQuraishi, Mohammed; Koytiger, Grigoriy; Jenney, Anne; MacBeath, Gavin; Sorger, Peter K. (2014)

Functional interpretation of genomic variation is critical to understanding human disease but it remains difficult to predict the effects of specific mutations on protein interaction networks and the phenotypes they regulate. ...