Now showing items 1-4 of 4

    • Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell 

      Zong, Chenghang; Chapman, Alec Randolph; Xie, Xiaoliang Sunney (American Association for the Advancement of Science, 2012)
      Kindred cells can have different genomes because of dynamic changes in DNA. Single cell sequencing is needed to characterize these genomic differences but has been hindered by whole-genome amplification bias, resulting in ...
    • Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing 

      Lu, Sijia; Zong, Chenghang; Fan, Wei; Yang, Mingyu; Li, Jinsen; Chapman, Alec Randolph; Zhu, Ping; Hu, Xuesong; Xu, Liya; Yan, Liying; Bai, Fan; Qiao, Jie; Tang, Fuchou; Li, Ruiqiang; Xie, Xiaoliang Sunney (American Association for the Advancement of Science, 2012)
      Meiotic recombination creates genetic diversity and ensures segregation of homologous chromosomes. Previous population analyses yielded results averaged among individuals and affected by evolutionary pressures. We sequenced ...
    • Rare event of histone demethylation can initiate singular gene expression of olfactory receptors 

      Tan, Longzhi; Zong, Chenghang; Xie, Xiaoliang Sunney (Proceedings of the National Academy of Sciences, 2013)
      In mammals, the sense of odors relies on the peculiar expression pattern of olfactory receptors (ORs). Each single neuron chooses one, and only one, from all ∼1,400 OR genes that are present in a mouse genome. In neurobiology, ...
    • Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients 

      Ni, Xiaohui; Zhuo, Minglei; Su, Zhe; Duan, J.; Gao, Yan; Wang, Z.; Zong, Chenghang; Bai, H.; Chapman, Alec Randolph; Zhao, J.; Xu, L.; An, T.; Ma, Q.; Wang, Y.; Wu, M.; Sun, Y.; Wang, S.; Li, Z.; Yang, X.; Yong, Jun; Su, X.-D.; Lu, Y.; Bai, F.; Xie, Xiaoliang Sunney; Wang, J. (Proceedings of the National Academy of Sciences, 2013)
      Circulating tumor cells (CTCs) enter peripheral blood from primary tumors and seed metastases. The genome sequencing of CTCs could offer noninvasive prognosis or even diagnosis, but has been hampered by low single-cell ...