Browsing by Author "Lawler, Jack"
Now showing items 1-11 of 11
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Combined therapy with thrombospondin-1 type I repeats (3TSR) and chemotherapy induces regression and significantly improves survival in a preclinical model of advanced stage epithelial ovarian cancer
Russell, S.; Duquette, M.; Liu, Joyce Ying; Drapkin, Ronny I.; Lawler, Jack William; Petrik, J. (FASEB, 2014)Most women are diagnosed with epithelial ovarian cancer (EOC) at advanced stage, where therapies have limited effectiveness and the long-term survival rate is low. We evaluated the effects of combined antiangiogenic and ... -
Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets
Olerud, Johan; Johansson, Magnus; Lawler, Jack William; Welsh, Nils; Carlsson, Per-Ola (American Diabetes Association, 2008)Objective: Insufficient development of a new intra-islet capillary network after transplantation may be one contributing factor to the failure of islet grafts in clinical transplantation. The present study tested the ... -
The Interaction of Thrombospondins with Extracellular Matrix Proteins
Tan, Kemin; Lawler, Jack William (Springer Netherlands, 2009)The thrombospondins (TSPs) are a family of five matricellular proteins that appear to function as adapter molecules to guide extracellular matrix synthesis and tissue remodeling in a variety of normal and disease settings. ... -
Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity
Duquette, Mark; Nadler, Monica; Okuhara, Dayne; Thompson, Jill; Shuttleworth, Trevor; Lawler, Jack (2014)The thrombospondins (TSPs) are a family of matricellular proteins that regulate cellular phenotype through interactions with a myriad of other proteins and proteoglycans. We have identified a novel interaction of the members ... -
Roles of Thrombospondin-1 and -2 in Regulating Corneal and Iris Angiogenesis
Cursiefen, Claus; Masli, Sharmila; Ng, Tat Fong; Dana, M.; Bornstein, Paul; Lawler, Jack William; Streilein, J. Wayne (Association for Research in Vision and Ophthalmology (ARVO), 2004)purpose. Thrombospondin (TSP)-1 and -2 are important antiangiogenic factors thought to be involved in maintaining corneal avascularity (angiogenic privilege). This study was undertaken to investigate whether deficiencies ... -
SCF\(^{β-TRCP}\) Suppresses Angiogenesis and Thyroid Cancer Cell Migration by Promoting Ubiquitination and Destruction of VEGF Receptor 2
Shaik, Shavali; Nucera, Carmelo; Inuzuka, Hiroyuki; Gao, Daming; Garnaas, Maija; Frechette, Gregory Martin; Harris, Lauren; Wan, Lixin; Fukushima, Hidefumi; Husain, Amjad; Nose, Vania; Fadda, Guido; Sadow, Peter Mark; Goessling, Wolfram; North, Trista Elizabeth; Lawler, Jack William; Wei, Wenyi (The Rockefeller University Press, 2012)The incidence of human papillary thyroid cancer (PTC) is increasing and an aggressive subtype of this disease is resistant to treatment with vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor. VEGFR2 promotes ... -
The Structure of the Ca\(^{2+}\)-binding, Glycosylated F-spondin Domain of F-spondin - A C2-Domain Variant in an Extracellular Matrix Protein
Tan, Kemin; Lawler, Jack William (BioMed Central, 2011)Background: F-spondin is a multi-domain extracellular matrix (ECM) protein and a contact-repellent molecule that directs axon outgrowth and cell migration during development. The reelin_N domain and the F-spondin domain ... -
Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes
Cursiefen, Claus; Maruyama, Kazuichi; Bock, Felix; Saban, Daniel; Sadrai, Zahra; Lawler, Jack William; Dana, Reza; Masli, Sharmila (Rockefeller University Press, 2011)Lymphangiogenesis plays an important role in tumor metastasis and transplant outcome. Here, we show that thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein and naturally occurring inhibitor of ... -
Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis
Lopez-Dee, Zenaida P.; Chittur, Sridar V.; Patel, Hiral; Chinikaylo, Aleona; Lippert, Brittany; Patel, Bhumi; Lawler, Jack; Gutierrez, Linda S. (Public Library of Science, 2015)Colorectal Cancer (CRC) is one of the late complications observed in patients suffering from inflammatory bowel diseases (IBD). Carcinogenesis is promoted by persistent chronic inflammation occurring in IBD. Understanding ... -
Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells with BRAFV600E: New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment
Duquette, Mark; Sadow, Peter M.; Lawler, Jack; Nucera, Carmelo (Frontiers Media S.A., 2013)Background and Rationale: Anaplastic thyroid cancer (ATC) is characterized by pleomorphic cells, has a poor prognosis, is highly devastating disease, and is not curable. No reliable biomarkers of metastatic potential, ... -
Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for β-Cell Function
Olerud, Johan; Mokhtari, Dariush; Johansson, Magnus; Christoffersson, Gustaf; Lawler, Jack William; Welsh, Nils; Carlsson, Per-Ola (American Diabetes Association, 2011)OBJECTIVE: Loss of thrombospondin (TSP)-1 in pancreatic islets has been shown to cause islet hyperplasia. This study tested the hypothesis that endothelial-derived TSP-1 is important for β-cell function. RESEARCH DESIGN ...