Now showing items 1-20 of 58

    • Adaptive Evolution as a Predictor of Species-Specific Innate Immune Response 

      Webb, Andrew E.; Gerek, Z. Nevin; Morgan, Claire C.; Walsh, Thomas A.; Loscher, Christine E.; Edwards, Scott V.; O’Connell, Mary J. (Oxford University Press, 2015)
      It has been proposed that positive selection may be associated with protein functional change. For example, human and macaque have different outcomes to HIV infection and it has been shown that residues under positive ...
    • Ancestral Polymorphism of Mhc Class II Genes in Mice: Implications for Balancing Selection and the Mammalian Molecular Clock 

      Edwards, Scott; Chesnut, Kye; Satta, Yoko; Wakeland, Edward K. (Genetics Society of America, 1997)
      To investigate the evolutionary dynamics at Mhc class II DR genes of mice (genus Mus),we sequenced the peptide binding regions (PBRs) of 41 DRB (=E beta) genes and eight DRA (=E alpha) genes from 15 strains representing ...
    • Ancient horizontal transfers of retrotransposons between birds and ancestors of human pathogenic nematodes 

      Suh, Alexander; Witt, Christopher C.; Menger, Juliana; Sadanandan, Keren R.; Podsiadlowski, Lars; Gerth, Michael; Weigert, Anne; McGuire, Jimmy A.; Mudge, Joann; Edwards, Scott V.; Rheindt, Frank E. (Nature Publishing Group, 2016)
      Parasite host switches may trigger disease emergence, but prehistoric host ranges are often unknowable. Lymphatic filariasis and loiasis are major human diseases caused by the insect-borne filarial nematodes Brugia, ...
    • The Anolis Lizard Genome: An Amniote Genome without Isochores 

      Fujita, Matthew; Edwards, Scott V.; Ponting, Chris P. (Oxford University Press (OUP), 2011)
      Isochores are large regions of relatively homogeneous nucleotide composition and are present in the genomes of all mammals and birds that have been sequenced to date. The newly sequenced genome of Anolis carolinensis ...
    • Cis-regulatory sequence variation and association with Mycoplasma load in natural populations of the house finch (Carpodacus mexicanus) 

      Backström, Niclas; Shipilina, Daria; Blom, Mozes P K; Edwards, Scott V. (Blackwell Publishing Ltd, 2013)
      Characterization of the genetic basis of fitness traits in natural populations is important for understanding how organisms adapt to the changing environment and to novel events, such as epizootics. However, candidate ...
    • Comparative Genomics of the Major Histocompatibility Complex in Amniotes 

      Godinez, Ricardo (2013-03-18)
      The major histocompatibility complex region (MHC) is a multi gene family present in all jawed vertebrates, with a fundamental role in vertebrate immunity. More than two decades of studies have resulted in the characterization ...
    • Conflict between Genetic and Phenotypic Differentiation: The Evolutionary History of a ‘Lost and Rediscovered’ Shorebird 

      Rheindt, Frank Erwin; Székely, Tamás; Edwards, Scott V.; Lee, Patricia L. M.; Burke, Terry; Kennerley, Peter R.; Bakewell, David N.; Alrashidi, Monif; Kosztolányi, András; Weston, Michael A.; Liu, Wei-Ting; Lei, Wei-Pan; Shigeta, Yoshimitsu; Javed, Sálim; Zefania, Sama; Küpper, Clemens (Public Library of Science (PLoS), 2011)
      Understanding and resolving conflicts between phenotypic and genetic differentiation is central to evolutionary research. While phenotypically monomorphic species may exhibit deep genetic divergences, some morphologically ...
    • Estimating phylogenetic trees from genome-scale data 

      Liu, Liang; Xi, Zhenxiang; Wu, Shaoyuan; Davis, Charles Cavender; Edwards, Scott V. (Wiley-Blackwell, 2015)
      The heterogeneity of signals in the genomes of diverse organisms poses challenges for traditional phylogenetic analysis. Phylogenetic methods known as “species tree” methods have been proposed to directly address one ...
    • The Evolution of Intron Size in Amniotes: A Role for Powered Flight? 

      Zhang, Qu; Edwards, Scott V. (Oxford University Press, 2012)
      Intronic DNA is a major component of eukaryotic genes and genomes and can be subject to selective constraint and have functions in gene regulation. Intron size is of particular interest given that it is thought to be the ...
    • The Evolution of Major Histocompatibility Complex in Birds 

      Hess, Christopher M.; Edwards, Scott (American Institute of Biological Sciences, 2002)
    • Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor 

      Baldwin, Maude Wheeler; Toda, Y.; Nakagita, T.; O'Connell, Mary J.; Klasing, Kirk C.; Misaka, T.; Edwards, Scott V.; Liberles, Stephen D (American Association for the Advancement of Science (AAAS), 2014)
      Sensory systems define an animal's capacity for perception and can evolve to promote survival in new environmental niches. We have uncovered a noncanonical mechanism for sweet taste perception that evolved in hummingbirds ...
    • Evolutionary Dynamics of Intron Size, Genome Size, and Physiological Correlates in Archosaurs 

      Waltari, Eric; Edwards, Scott (University of Chicago Press, 2002)
      It has been proposed that intron and genome sizes in birds are reduced in comparison with mammals because of the metabolic demands of flight. To test this hypothesis, we examined the sizes of 14 introns in a nonflying ...
    • Exploration of Phylogenetic Data using a Global Sequence Analysis Method 

      Chapus, Charles; Dufraigne, Christine; Edwards, Scott; Giron, Alain; Fertil, Bernard; Deschavanne, Patrick (BioMed Central, 2005)
      Background: Molecular phylogenetic methods are based on alignments of nucleic or peptidic sequences. The tremendous increase in molecular data permits phylogenetic analyses of very long sequences and of many species, but ...
    • Feather development genes and associated regulatory innovation predate the origin of Dinosauria 

      Lowe, Craig B.; Clarke, Julia A.; Baker, Allan J.; Haussler, D.; Edwards, Scott V. (Oxford University Press (OUP), 2014)
      The evolution of avian feathers have recently been illuminated by fossils and the identification of genes involved in feather patterning and morphogenesis. However, molecular studies have focused mainly on protein-coding ...
    • Future of Avian Genetic Resources Collections: Archives of Evolutionary and Environmental History 

      Edwards, Scott; Birks, Sharon; Brumfield, Robb T.; Hanner, Robert (American Ornithologists' Union, 2005)
    • Gene Duplication and Fragmentation in the Zebra Finch Major Histocompatibility Complex 

      Balakrishnan, Christopher N; Ekblom, Robert; Völker, Martin; Westerdahl, Helena; Kotkiewicz, Holly; Burt, David W; Graves, Tina; Griffin, Darren K; Warren, Wesley C; Godinez, Ricardo; Edwards, Scott V. (BioMed Central, 2010)
      Background: Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. Avian MHC organization is of ...
    • Genetic Introgression: An Integral but neglected component of speciation in birds 

      Rheindt, Frank Erwin; Edwards, Scott V. (University of California Press, 2011)
      HYBRIDIZATION, OR THE act of reproduction between different species, is common in birds (Grant and Grant 1992) and can be an agent of adaptive evolution (Veen et al. 2001). When hybridization occurs, a species' genetic ...
    • Genome Evolution in Reptilia: in silico Chicken Mapping of 12,000 BAC-end Sequences from Two Reptiles and a Basal Bird 

      Chapus, Charles; Edwards, Scott V. (BioMed Central, 2009)
      Background: With the publication of the draft chicken genome and the recent production of several BAC clone libraries from non-avian reptiles and birds, it is now possible to undertake more detailed comparative genomic ...
    • The genome of the green anole lizard and a comparative analysis with birds and mammals 

      Alföldi, Jessica; Di Palma, Federica; Grabherr, Manfred; Williams, Christina; Kong, Lesheng; Mauceli, Evan; Russell, Pamela; Lowe, Craig B.; Glor, Richard E.; Jaffe, Jacob D.; Ray, David A.; Boissinot, Stephane; Shedlock, Andrew M.; Botka, Christopher; Castoe, Todd A.; Colbourne, John K.; Fujita, Matthew; Moreno, Ricardo Godinez; ten Hallers, Boudewijn F.; Haussler, David; Heger, Andreas; Heiman, David; Janes, Daniel E.; Johnson, Jeremy; de Jong, Pieter J.; Koriabine, Maxim Y.; Lara, Marcia; Novick, Peter A.; Organ, Chris L.; Peach, Sally E.; Poe, Steven; Pollock, David D.; de Queiroz, Kevin; Sanger, Thomas; Searle, Steve; Smith, Jeremy D.; Smith, Zachary; Swofford, Ross; Turner-Maier, Jason; Wade, Juli; Young, Sarah; Zadissa, Amonida; Edwards, Scott V.; Glenn, Travis C.; Schneider, Christopher; Losos, Jonathan; Lander, Eric Steven; Breen, Matthew; Ponting, Chris P.; Lindblad-Toh, Kerstin (Nature Publishing Group, 2011)
      The evolution of the amniotic egg was one of the great evolutionary innovations in the history of life, freeing vertebrates from an obligatory connection to water and thus permitting the conquest of terrestrial environments. ...
    • High Gene Flow on a Continental Scale in the Polyandrous Kentish Plover Charadrius alexandrinus 

      Küpper, Clemens; Edwards, Scott V.; Kosztolányi, András; Alrashidi, Monif; Burke, Terry; Herrmann, Philipp; Argüelles-Tico, Araceli; Amat, Juan A.; Amezian, Mohamed; Rocha, Afonso; Hötker, Hermann; Ivanov, Anton; Chernicko, Joseph; Székely, Tamás (Wiley Blackwell (Blackwell Publishing), 2012)
      Gene flow promotes genetic homogeneity of species in time and space. Gene flow can be modulated by sex-biased dispersal that links population genetics to mating systems. We investigated the phylogeography of the widely ...