Now showing items 1-7 of 7

    • B Cell Antigen Receptor Signal Strength and Peripheral B Cell Development are Regulated by a 9-O-Acetyl Sialic Acid Esterase 

      Cariappa, Annaiah; Takematsu, Hiromu; Liu, Haoyuan; Diaz, Sandra; Haider, Khaleda; Kalloo, Geetika; Varki, Nissi; Varki, Ajit; Boboila, Cristian; Connole, Michelle Ann; Shi, Hai Ning; Pillai, Shiv Subramaniam (Rockefeller University Press, 2009)
      We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that ...
    • Discovery and characterization of the ligands of NK-cell receptors implicated in human diseases 

      Garcia Beltran, Wilfredo F. (2016-08-31)
      Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that act as first-line defenders against intracellular pathogens. Their functions are dictated by germline-encoded activating and inhibitory ...
    • Elucidation of plasmacytoid dendritic cell development 

      Netravali, Ilka Arun (2014-06-06)
      Most currently defined hematopoietic progenitor pools are heterogeneous, contributing to uncertainty regarding the development of certain blood cells. The origins of plasmacytoid dendritic cells, for instance, have long ...
    • Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16 

      Gunn, Bronwyn; Schneider, Jeffrey; Shansab, Maryam; Bastian, Arangassery Rosemary; Fahrbach, Kelly; Smith, Archer; Mahan, Alison; Karim, Marcus; Licht, Anna; Zvonar, Ivan; Tedesco, Jacquelynn; Anderson, Meegan; Chapel, Anais; Suscovich, Todd; Malaspina, David; Streeck, Hendrik; Walker, Bruce D.; Kim, Arthur; Lauer, Georg; Altfeld, Marcus; Pillai, Shiv; Szleifer, Igal; Kelleher, Neil L.; Kiser, Patrick F.; Hope, Thomas J.; Alter, Galit (2016)
      Transmission of HIV across mucosal barriers accounts for the majority of HIV infections worldwide. Thus, efforts aimed at enhancing protective immunity at these sites are a top priority, including increasing virus-specific ...
    • M89V Sialic Acid Acetyl Esterase (SIAE) and All Other Non-Synonymous Common Variants of This Gene Are Catalytically Normal 

      Chellappa, Vasant; Taylor, Kendra N; Pedrick, Kathryn; Donado, Carlos; Netravali, Ilka Arun; Haider, Khaleda; Cariappa, Annaiah; Dalomba, Natasha F.; Pillai, Shiv Subramaniam (Public Library of Science, 2013)
      Catalytically defective rare variants of Sialic acid Acetyl Esterase (SIAE) have previously been linked to autoimmunity. Studies presented here confirm that the M89V SIAE protein and all other products of common variant ...
    • Neutralizing Anti-HIV Antibodies Develop in a Humanized Mouse Model of HIV-1 Infection 

      Vrbanac, Vladimir; Tivey, T; Cariappa, A; Seung, Edward N.; Dugast, Anne-Sophie; Dudek, Timothy E; Mattoo, Hamid Rasheed; Murooka, Thomas; Pillai, Shiv Subramaniam; Tager, Andrew Martin; Luster, Andrew David (BioMed Central, 2012)
    • A unique B2 B cell subset in the intestine 

      Shimomura, Yasuyo; Ogawa, Atsuhiro; Kawada, Mayumi; Sugimoto, Ken; Mizoguchi, Atsushi; Shi, Hai-Ning; Pillai, Shiv Subramaniam; Bhan, Atul Kumar (The Rockefeller University Press, 2008)
      Over 80% of the body's activated B cells are located in mucosal sites, including the intestine. The intestine contains IgM[super]+ B cells, but these cells have not been characterized phenotypically or in terms of their ...