Now showing items 1-7 of 7

    • CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival 

      D’Addio, Francesca; Ueno, Takuya; Clarkson, Michael; Zhu, Baogong; Vergani, Andrea; Freeman, Gordon James; Sayegh, Mohamed Hassan; Ansari, Mohammed Javeed I.; Fiorina, Paolo; Habicht, Antje (Public Library of Science, 2013)
      CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8+ cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, ...
    • IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response 

      Petrelli, Alessandra; Carvello, Michele; Du, Ming; Chengwen, Liu; Mfarrej, Bechara G.; Hwu, Patrick; Secchi, Antonio; Leonard, Warren J.; Young, Deborah; Zajac, Allan J.; Vergani, Andrea; Lee, Kang Mi; Tezza, Sara; Kleffel, Sonja Beate; Sayegh, Mohamed Hassan; Markmann, James F.; Fiorina, Paolo (American Diabetes Association, 2011)
      Objective: Interleukin-21 (IL-21) is a proinflammatory cytokine that has been shown to affect Treg/Teff balance. However, the mechanism by which IL-21 orchestrates alloimmune response and interplays with Tregs is still ...
    • Inotuzumab Ozogamicin Murine Analog–Mediated B-Cell Depletion Reduces Anti-islet Allo- and Autoimmune Responses 

      Carvello, Michele; Petrelli, Alessandra; Vergani, Andrea; Lee, Kang Mi; Tezza, Sara; Chin, Melissa; Orsenigo, Elena; Staudacher, Carlo; Secchi, Antonio; Dunussi-Joannopoulos, Kyri; Sayegh, Mohamed Hassan; Markmann, James F.; Fiorina, Paolo (American Diabetes Association, 2012)
      B cells participate in the priming of the allo- and autoimmune responses, and their depletion can thus be advantageous for islet transplantation. Herein, we provide an extensive study of the effect of B-cell depletion in ...
    • Near Normalization of Metabolic and Functional Features of the Central Nervous System in Type 1 Diabetic Patients With End-Stage Renal Disease After Kidney-Pancreas Transplantation 

      Fiorina, Paolo; Vezzulli, Paolo; Bassi, Roberto; Gremizzi, Chiara; Falautano, Monica; D’Addio, Francesca; Vergani, Andrea; Chabtini, Lola; Altamura, Erica; Mello, Alessandra; Caldara, Rossana; Scavini, Marina; Magnani, Giuseppe; Falini, Andrea; Secchi, Antonio (American Diabetes Association, 2012)
      OBJECTIVE The pathogenesis of brain disorders in type 1 diabetes (T1D) is multifactorial and involves the adverse effects of chronic hyperglycemia and of recurrent hypoglycemia. Kidney-pancreas (KP), but not kidney alone ...
    • Prolonged, Low-Dose Anti-Thymocyte Globulin, Combined with CTLA4-Ig, Promotes Engraftment in a Stringent Transplant Model 

      D’Addio, Francesca; Boenisch, Olaf; Magee, Ciara N; Yeung, Melissa; Yuan, Xueli; Mfarrej, Bechara; Vergani, Andrea; Ansari, Mohammed Javeed; Fiorina, Paolo; Najafian, Nader (Public Library of Science, 2013)
      Background: Despite significant nephrotoxicity, calcineurin inhibitors (CNIs) remain the cornerstone of immunosuppression in solid organ transplantation. We, along with others, have reported tolerogenic properties of ...
    • Regenerative Therapies for Diabetic Microangiopathy 

      Bassi, Roberto; Trevisani, Alessio; Tezza, Sara; Ben Nasr, Moufida; Gatti, Francesca; Vergani, Andrea; Farina, Antonio; Fiorina, Paolo (Hindawi Publishing Corporation, 2012)
      Hyperglycaemia occurring in diabetes is responsible for accelerated arterial remodeling and atherosclerosis, affecting the macro- and the microcirculatory system. Vessel injury is mainly related to deregulation of glucose ...
    • Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes 

      Dada, Shirine; Wong, Masie; Law, Kenneth; Wu, Erxi; Dunussi-Joannopoulos, Kyri; Bluestone, Jeffrey; Fiorina, Paolo; Vergani, Andrea; Jurewicz, Mollie; Tian, Ze; Abdi, Reza; Guleria, Indira; Rodig, Scott J.; Sayegh, Mohamed Hassan (American Diabetes Association, 2008)
      OBJECTIVES—To investigate a B-cell–depleting strategy to reverse diabetes in naïve NOD mice. RESEARCH DESIGN AND METHODS—We targeted the CD22 receptor on B-cells of naïve NOD mice to deplete and reprogram B-cells to ...