Now showing items 1-5 of 5

    • Carbon Monoxide: Present and Future Indications for a Medical Gas 

      Ryter, Stefan W.; Choi, Augustine M.K. (The Korean Association of Internal Medicine, 2013)
      Gaseous molecules continue to hold new promise in molecular medicine as experimental and clinical therapeutics. The low molecular weight gas carbon monoxide (CO), and similar gaseous molecules (e.g., \(H_2S\), nitric oxide) ...
    • Egr-1 Regulates Autophagy in Cigarette Smoke-induced Chronic Obstructive Pulmonary Disease 

      Chen, Zhi-Hua; Kim, Hong Pyo; Sciurba, Frank C.; Feghali-Bostwick, Carol; Stolz, Donna B.; Dhir, Rajiv; Landreneau, Rodney J.; Schuchert, Mathew J.; Yousem, Samuel A.; Pilewski, Joseph M.; Lee, Janet S.; Zhang, Yingze; Lee, Seon-Jin; Nakahira, Kiichi; Ryter, Stefan W.; Choi, Augustine M.K. (Public Library of Science, 2008)
      Background: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is ...
    • Identifying Targets for COPD Treatment Through Gene Expression Analyses 

      Chen, Zhi-Hua; Kim, Hong Pyo; Ryter, Stefan W.; Choi, Augustine M.K. (Dove Medical Press, 2008)
      Despite the status of chronic obstructive pulmonary disease (COPD) as a major global health problem, no currently available therapies can limit COPD progression. Therefore, an urgent need exists for the development of new ...
    • The Influence of Radiographic Phenotype and Smoking Status on Peripheral Blood Biomarker Patterns in Chronic Obstructive Pulmonary Disease 

      Bon, Jessica M.; Leader, Joseph K.; Weissfeld, Joel L.; Coxson, Harvey O.; Branch, Robert A.; Kondragunta, Venkateswarlu; Lee, Janet S.; Zhang, Yingze; Lokshin, Anna E.; Kaminski, Naftali; Gur, David; Sciurba, Frank C.; Zheng, Bin; Choi, Augustine M.K. (Public Library of Science, 2009)
      Background: Chronic obstructive pulmonary disease (COPD) is characterized by both airway remodeling and parenchymal destruction. The identification of unique biomarker patterns associated with airway dominant versus ...
    • Mitogen-Activated Protein Kinases Regulate Susceptibility to Ventilator-Induced Lung Injury 

      Dolinay, Tamás; Wu, Wei; Kaminski, Naftali; Ifedigbo, Emeka; Kaynar, A. Murat; Szilasi, Mária; Watkins, Simon C.; Ryter, Stefan W.; Hoetzel, Alexander; Choi, Augustine M.K. (Public Library of Science, 2008)
      Background: Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance ...