Now showing items 1-7 of 7

    • Kim-1/Tim-1 and Immune Cells: Shifting Sands 

      Ichimura, Takaharu; Brooks, Craig; Bonventre, Joseph Vincent (Nature Publishing Group, 2012)
      Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory ...
    • Loss of Leucine-rich Repeat Kinase 2 Causes Age-dependent Bi-phasic Alterations of the Autophagy Pathway 

      Tong, Youren; Giaime, Emilie; Yamaguchi, Hiroo; Ichimura, Takaharu; Liu, Yumin; Si, Huiqing; Cai, Huaibin; Bonventre, Joseph Vincent; Shen, Jie (BioMed Central, 2012)
      Background: Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously ...
    • Meclizine Preconditioning Protects the Kidney Against Ischemia–Reperfusion Injury 

      Kishi, Seiji; Campanholle, Gabriela; Gohil, Vishal M.; Perocchi, Fabiana; Brooks, Craig R.; Morizane, Ryuji; Sabbisetti, Venkata; Ichimura, Takaharu; Mootha, Vamsi K.; Bonventre, Joseph V. (Elsevier, 2015)
      Global or local ischemia contributes to the pathogenesis of acute kidney injury (AKI). Currently there are no specific therapies to prevent AKI. Potentiation of glycolytic metabolism and attenuation of mitochondrial ...
    • Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report 

      Bassi, Roberto; Vergani, Andrea; D’Addio, Francesca; Nasr, Moufida Ben; Mocci, Alessio; Rastaldi, Maria Pia; Ichimura, Takaharu; Vincent Bonventre, Joseph; Fiorina, Paolo (Springer International Publishing, 2014)
      Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a ...
    • Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis 

      Besschetnova, Tatiana Y.; Ichimura, Takaharu; Katebi, Negin; St. Croix, Brad; Bonventre, Joseph V.; Olsen, Bjorn R. (2015)
      It is well known that angiogenesis is linked to fibrotic processes in fibroproliferative diseases, but insights into pathophysiological processes are limited, due to lack of understanding of molecular mechanisms controlling ...
    • Secreted Factors from Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury 

      Yarmush, Joshua S.; Milwid, John Miles; Ichimura, Takaharu; Li, Matthew; Jiao, Joy; Lee, Jungwoo; Parekkadan, Biju; Tilles, Arno W.; Bonventre, Joseph Vincent; Yarmush, Martin Leon (Hindawi Publishing Corporation, 2012)
      Acute kidney injury is a devastating syndrome that afflicts over 2,000,000 people in the US per year, with an associated mortality of greater than 70% in severe cases. Unfortunately, standard-of-care treatments are not ...
    • Targeted Proximal Tubule Injury Triggers Interstitial Fibrosis and Glomerulosclerosis 

      Grgic, Ivica; Campanholle, Gabriela; Bijol, Vanesa; Wang, Chang; Sabbisetti, Venkata S; Ichimura, Takaharu; Humphreys, Benjamin D.; Bonventre, Joseph Vincent (Nature Publishing Group, 2012)
      Chronic kidney disease (CKD) remains one of the leading causes of death in the developed world and acute kidney injury (AKI) is now recognized as a major risk factor in its development. Understanding the factors leading ...