Now showing items 1-7 of 7

    • Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis 

      Wei, Jun; Long, Lingyun; Yang, Kai; Guy, Cliff; Shrestha, Sharad; Chen, Zuojia; Wu, Chuan; Vogel, Peter; Neale, Geoffrey; Green, Douglas R; Chi, Hongbo (2015)
      Regulatory T (Treg) cells respond to immune and inflammatory signals to mediate immunosuppression, but how functional integrity of Treg cells is maintained under activating environments remains elusive. Here we found that ...
    • Dynamic regulatory network controlling Th17 cell differentiation 

      Yosef, Nir; Shalek, Alex K.; Gaublomme, Jellert T.; Jin, Hulin; Lee, Youjin; Awasthi, Amit; Wu, Chuan; Karwacz, Katarzyna; Xiao, Sheng; Jorgolli, Marsela; Gennert, David; Satija, Rahul; Shakya, Arvind; Lu, Diana Y.; Trombetta, John J.; Pillai, Meenu R.; Ratcliffe, Peter J.; Coleman, Mathew L.; Bix, Mark; Tantin, Dean; Park, Hongkun; Kuchroo, Vijay K.; Regev, Aviv (2013)
      Despite their importance, the molecular circuits that control the differentiation of naïve T cells remain largely unknown. Recent studies that reconstructed regulatory networks in mammalian cells have focused on short-term ...
    • IL-21 induces IL-22 production in CD4+ T-cells 

      Yeste, Ada; Mascanfroni, Ivan D.; Nadeau, Meghan; Burns, Evan J.; Tukpah, Ann-Marcia; Santiago, Andrezza; Wu, Chuan; Patel, Bonny; Kumar, Deepak; Quintana, Francisco J. (2014)
      IL-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defense and mucosal homeostasis, thus it is important to investigate the mechanisms that regulate IL-22 production. We ...
    • An IL-27/NFIL3 signaling axis drives Tim-3 and IL-10 expression and T cell dysfunction 

      Zhu, Chen; Sakuishi, Kaori; Xiao, Sheng; Sun, Zhiyi; Zaghouani, Sarah; Gu, Guangxiang; Wang, Chao; Tan, Dewar J.; Wu, Chuan; Rangachari, Manu; Pertel, Thomas; Jin, Hyun-Tak; Ahmed, Rafi; Anderson, Ana C.; Kuchroo, Vijay K. (2015)
      SUMMARY The inhibitory receptor Tim-3 has emerged as a critical regulator of the T cell dysfunction that develops in chronic viral infections and cancers. However, little is known regarding the signaling pathways that drive ...
    • Induction and molecular signature of pathogenic TH17 cells 

      Lee, Youjin; Awasthi, Amit; Yosef, Nir; Quintana, Francisco Javier; Xiao, Sheng; Peters, Anneli; Wu, Chuan; Kleinewietfeld, Markus; Kunder, Sharon R.; Hafler, David A.; Sobel, Raymond A.; Regev, Aviv; Kuchroo, Vijay Kumar (2012)
      Interleukin 17 (IL-17)-producing TH17 cells are often present at the sites of tissue inflammation in autoimmune diseases, which has lead to the conclusion that TH17 are main drivers of autoimmune tissue injury. However, ...
    • Induction of pathogenic Th17 cells by inducible salt sensing kinase SGK1 

      Wu, Chuan; Yosef, Nir; Thalhamer, Theresa; Zhu, Chen; Xiao, Sheng; Kishi, Yasuhiro; Regev, Aviv; Kuchroo, Vijay (2013)
      Th17 cells are highly proinflammatory cells critical for clearing extracellular pathogens and for induction of multiple autoimmune diseases1. IL-23 plays a critical role in stabilizing and reinforcing the Th17 phenotype ...
    • Tiam1/Rac1 complex controls Il17a transcription and autoimmunity 

      Kurdi, Ahmed T.; Bassil, Ribal; Olah, Marta; Wu, Chuan; Xiao, Sheng; Taga, Mariko; Frangieh, Michael; Buttrick, Thomas; Orent, William; Bradshaw, Elizabeth M.; Khoury, Samia J.; Elyaman, Wassim (Nature Publishing Group, 2016)
      RORγt is a master transcription factor of Th17 cells and considered as a promising drug target for the treatment of autoimmune diseases. Here, we show the guanine nucleotide exchange factor, Tiam1, and its cognate Rho-family ...