Now showing items 1-13 of 13

    • Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD 

      Chu, Jen-hwa; Hersh, Craig P; Castaldi, Peter J; Cho, Michael H; Raby, Benjamin A; Laird, Nan; Bowler, Russell; Rennard, Stephen; Loscalzo, Joseph; Quackenbush, John; Silverman, Edwin K (BioMed Central, 2014)
      Background: The investigation of complex disease heterogeneity has been challenging. Here, we introduce a network-based approach, using partial correlations, that analyzes the relationships among multiple disease-related ...
    • Bone Morphogenetic Protein‐2 Decreases MicroRNA‐30b and MicroRNA‐30c to Promote Vascular Smooth Muscle Cell Calcification 

      Balderman, Joshua A. F.; Lee, Hae‐Young; Mahoney, Christopher E.; Handy, Diane Elizabeth; White, Kevin; Annis, Sofia; Lebeche, Djamel; Hajjar, Roger J.; Loscalzo, Joseph; Leopold, Jane Anne (Blackwell Publishing Ltd, 2012)
      Background: Vascular calcification resembles bone formation and involves vascular smooth muscle cell (SMC) transition to an osteoblast‐like phenotype to express Runx2, a master osteoblast transcription factor. One possible ...
    • Caveolin 1 Modulates Aldosterone‐Mediated Pathways of Glucose and Lipid Homeostasis 

      Baudrand, Rene; Gupta, Nidhi; Garza, Amanda E.; Vaidya, Anand; Leopold, Jane A.; Hopkins, Paul N.; Jeunemaitre, Xavier; Ferri, Claudio; Romero, Jose R.; Williams, Jonathan; Loscalzo, Joseph; Adler, Gail K.; Williams, Gordon H.; Pojoga, Luminita H. (John Wiley and Sons Inc., 2016)
      Background: Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav‐1) is involved in glucose/lipid homeostasis and may modulate MR ...
    • Complexity and network dynamics in physiological adaptation: An integrated view 

      Baffy, Gyorgy; Loscalzo, Joseph (Elsevier BV, 2014)
      Living organisms constantly interact with their surroundings and sustain internal stability against perturbations. This dynamic process follows three fundamental strategies (restore, explore, and abandon) articulated in ...
    • DiseaseConnect: a comprehensive web server for mechanism-based disease–disease connections 

      Liu, Chun-Chi; Tseng, Yu-Ting; Li, Wenyuan; Wu, Chia-Yu; Mayzus, Ilya; Rzhetsky, Andrey; Sun, Fengzhu; Waterman, Michael; Chen, Jeremy J. W.; Chaudhary, Preet M.; Loscalzo, Joseph; Crandall, Edward; Zhou, Xianghong Jasmine (Oxford University Press, 2014)
      The DiseaseConnect (http://disease-connect.org) is a web server for analysis and visualization of a comprehensive knowledge on mechanism-based disease connectivity. The traditional disease classification system groups ...
    • Endophenotype Network Models: Common Core of Complex Diseases 

      Ghiassian, Susan Dina; Menche, Jörg; Chasman, Daniel I.; Giulianini, Franco; Wang, Ruisheng; Ricchiuto, Piero; Aikawa, Masanori; Iwata, Hiroshi; Müller, Christian; Zeller, Tania; Sharma, Amitabh; Wild, Philipp; Lackner, Karl; Singh, Sasha; Ridker, Paul M.; Blankenberg, Stefan; Barabási, Albert-László; Loscalzo, Joseph (Nature Publishing Group, 2016)
      Historically, human diseases have been differentiated and categorized based on the organ system in which they primarily manifest. Recently, an alternative view is emerging that emphasizes that different diseases often have ...
    • Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series) 

      Loscalzo, Joseph; Handy, Diane E. (University of Chicago Press, 2014)
      Abstract Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action. In the cardiovascular ...
    • Incorporation of heparin-binding proteins into preformed dextran sulfate-chitosan nanoparticles 

      Zaman, Paula; Wang, Julia; Blau, Adam; Wang, Weiping; Li, Tina; Kohane, Daniel S; Loscalzo, Joseph; Zhang, Ying-Yi (Dove Medical Press, 2016)
      Incorporation of proteins into dextran sulfate (DS)-chitosan (CS) nanoparticles (DSCS NPs) is commonly performed using entrapment procedures, in which protein molecules are mixed with DS and CS until particle formation ...
    • Increasing Glucose 6-Phosphate Dehydrogenase Activity Restores Redox Balance in Vascular Endothelial Cells Exposed to High Glucose 

      Zhang, Zhaoyun; Yang, Zhihong; Zhu, Bo; Hu, Ji; Liew, Chong-Wee; Leopold, Jane Anne; Handy, Diane Elizabeth; Loscalzo, Joseph; Stanton, Robert Carl; Zhang, Ying-Yi (Public Library of Science, 2012)
      Previous studies have shown that high glucose increases reactive oxygen species (ROS) in endothelial cells that contributes to vascular dysfunction and atherosclerosis. Accumulation of ROS is due to dysregulated redox ...
    • On the Nose 

      Abdalla, Marwah; Sax, Paul Edward; Mostaghimi, Arash; Miller, Amy Leigh; Loscalzo, Joseph (New England Journal of Medicine (NEJM/MMS), 2015)
      A 67-year-old man presented with a 3-day history of chest tightness, wheezing, coughing, and dyspnea. He had a history of asthma but had not had major exacerbations for 20 years. He did not have fever, sputum production, ...
    • Randomized Controlled Trial of Social Media: Effect of Increased Intensity of the Intervention 

      Fox, Caroline S.; Gurary, Ellen B.; Ryan, John; Bonaca, Marc; Barry, Karen; Loscalzo, Joseph; Massaro, Joseph (John Wiley and Sons Inc., 2016)
      Background: A prior randomized controlled trial of social media exposure at Circulation determined that social media did not increase 30‐day page views. Whether insufficient social media intensity contributed to these ...
    • Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case 

      Garmaroudi, Farshid S.; Handy, Diane E.; Liu, Yang-Yu; Loscalzo, Joseph (Public Library of Science, 2016)
      Impaired nitric oxide (NO˙)-cyclic guanosine 3', 5'-monophosphate (cGMP) signaling has been observed in many cardiovascular disorders, including heart failure and pulmonary arterial hypertension. There are several enzymatic ...
    • Tissue Specificity of Human Disease Module 

      Kitsak, Maksim; Sharma, Amitabh; Menche, Jörg; Guney, Emre; Ghiassian, Susan Dina; Loscalzo, Joseph; Barabási, Albert-László (Nature Publishing Group, 2016)
      Genes carrying mutations associated with genetic diseases are present in all human cells; yet, clinical manifestations of genetic diseases are usually highly tissue-specific. Although some disease genes are expressed only ...