Browsing by Author "Liu, Pengda"
Now showing items 1-8 of 8
-
Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis
Dai, Xiangpeng; Liu, Pengda; Lau, Alan W; Liu, Yueyong; Inuzuka, Hiroyuki (Blackwell Publishing Ltd, 2014)Induced pluripotent stem (iPS) cells can be generated from somatic cells by coexpression of four transcription factors: Sox2, Oct4, Klf4, and c-Myc. However, the low efficiency in generating iPS cells and the tendency of ... -
DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction
Wang, Zhiwei; Inuzuka, Hiroyuki; Zhong, Jiateng; Fukushima, Hidefumi; Wan, Lixin; Liu, Pengda; Wei, Wenyi (Impact Journals LLC, 2012)The Mdm2 oncoprotein promotes p53 ubiquitination and destruction. Yet, exact molecular mechanisms of Mdm2 destruction itself, under DNA damaging conditions, remain unclear. Recently, we identified SCFβ-TRCP as a novel E3 ... -
Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity
Liu, Pengda; Guo, Jianping; Gan, Wenjian; Wei, Wenyi (Higher Education Press, 2014)Mammalian target of rapamycin (mTOR) plays essential roles in cell proliferation, survival and metabolism by forming at least two functional distinct multi-protein complexes, mTORC1 and mTORC2. External growth signals can ... -
Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2
Wang, Zhiwei; Inuzuka, Hiroyuki; Zhong, Jiateng; Liu, Pengda; Sarkar, Fazlul H.; Sun, Yi; Wei, Wenyi (Impact Journals LLC, 2012)The Skp2 (S-phase kinase associated protein 2) oncoprotein is often highly expressed in various types of human cancers. However, the mechanistic basis of its oncogenic function, as well as the upstream regulatory pathway(s) ... -
Mcl-1 Ubiquitination and Destruction
Inuzuka, Hiroyuki; Fukushima, Hidefumi; Shaik, Shavali; Liu, Pengda; Lau, Alan W.; Wei, Wenyi (Impact Journals LLC, 2011)Loss of the Fbw7 tumor suppressor is common in diverse human cancer types, including T-Cell Acute Lymphoblastic Leukemia (T-ALL), although the mechanistic basis of its anti-oncogenic activity remains largely unclear. We ... -
SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway
Liu, Jia; Wan, Lixin; Liu, Pengda; Inuzuka, Hiroyuki; Liu, Jiankang; Wang, Zhiwei; Wei, Wenyi (Impact Journals LLC, 2014)The HECT domain-containing ubiquitin E3 ligase NEDD4 is widely expressed in mammalian tissues and plays a crucial role in governing a wide spectrum of cellular processes including cell growth, tissue development and ... -
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis
Liu, Pengda; Gan, Wenjian; Inuzuka, Hiroyuki; Lazorchak, Adam S; Gao, Daming; Arojo, Omotooke; Liu, Dou; Wan, Lixin; Zhai, Bo; Yu, Yonghao; Yuan, Min; Kim, Byeong Mo; Shaik, Shavali; Menon, Suchithra; Gygi, Steven P.; Lee, Tae Ho; Asara, John M; Manning, Brendan D.; Blenis, John; Su, Bing; Wei, Wenyi (2013)The mechanistic target of rapamycin (mTOR) functions as a critical regulator of cellular growth and metabolism by forming multi-component, yet functionally distinct complexes mTORC1 and mTORC2. Although mTORC2 has been ... -
Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy
Kim, Byeong Mo; Hong, Yunkyung; Lee, Seunghoon; Liu, Pengda; Lim, Ji Hong; Lee, Yong Heon; Lee, Tae Ho; Chang, Kyu Tae; Hong, Yonggeun (MDPI, 2015)Ionizing radiation (IR), such as X-rays and gamma (γ)-rays, mediates various forms of cancer cell death such as apoptosis, necrosis, autophagy, mitotic catastrophe, and senescence. Among them, apoptosis and mitotic catastrophe ...